CAY10650

Base Information

• Chemical Name: CAY10650
• CAS No.: 1233706-88-1
• Molecular Formula: C₂₈H₂₅NO₆
• Molecular Weight: 471.51
• Mol file: 1233706-88-1.mol

Synonyms:1H-Pyrrole,3-iodo;3-Iodpyrrol;3-IODOPYRROLE;

Chemical Property of CAY10650

Chemical Property:

• Melting Point: 103-104℃
• Boiling Point: 685.4±55.0 °C(Predicted)
• PKA: 4.03±0.30(Predicted)
• PSA: 94.83000
• Density: 1.24±0.1 g/cm3(Predicted)
• LogP: 5.61860

Purity/Quality:

99%+, ^*data from raw suppliers

CAY10650 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process. CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor. It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis. The phase I metabolite of this compound, CAY10641 , is also available.

Technology Process of CAY10650

There total 1 articles about CAY10650 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

methyl 1-[2,2-diethoxy-3-(4-phenoxyphenoxy)propyl]-3-isobutanoylindole-5-carboxylate (1233707-23-7) → 3-isobutyryl-1-(2-oxo-3-(4-phenoxyphenoxy)propyl)-1H-indole-5-carboxylic acid (1233706-88-1)

Guidance literature:

methyl 1-[2,2-diethoxy-3-(4-phenoxyphenoxy)propyl]-3-isobutanoylindole-5-carboxylate; With sodium hydroxide; In methanol; water; for 5h; Reflux;

With hydrogenchloride; In tetrahydrofuran; methanol; water; for 3.5h; Reflux;

DOI:10.1021/jm1001088

upstream raw materials:

methyl 1-[2,2-diethoxy-3-(4-phenoxyphenoxy)propyl]-3-isobutanoylindole-5-carboxylate

Refernces