Benzo[b]thiophene-5-carboximidamide, 2-[[[4-[[1-(1-iminoethyl)-4-piperidinyl]oxy]phenyl](methylsulfonyl)amino]methyl]-

Base Information

• Chemical Name: Benzo[b]thiophene-5-carboximidamide, 2-[[[4-[[1-(1-iminoethyl)-4-piperidinyl]oxy]phenyl](methylsulfonyl)amino]methyl]-
• CAS No.: 364614-57-3
• Molecular Formula: C24H29N5O3S2
• Molecular Weight: 499.64876
• Mol file: 364614-57-3.mol

Synonyms:2-[[4-(1-ethanimidoylpiperidin-4-yl)oxy-N-methylsulfonylanilino]methyl]-1-benzothiophene-5-carboximidamide;Benzo[b]thiophene-5-carboxiMidaMide, 2-[[[4-[[1-(1-iMinoethyl)-4-piperidinyl]oxy]phenyl](Methylsulfonyl)aMino]Methyl]-

Chemical Property of Benzo[b]thiophene-5-carboximidamide, 2-[[[4-[[1-(1-iminoethyl)-4-piperidinyl]oxy]phenyl](methylsulfonyl)amino]methyl]-

Chemical Property:

• PSA: 160.19000
• LogP: 5.91040

Purity/Quality:

2-[[[4-[[1-(1-IMINOETHYL)-4-PIPERIDINYL]OXY]PHENYL](METHYLSULFONYL)AMINO]METHYL]BENZO[B]THIOPHENE-5-CARBOXIMIDAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzo[b]thiophene-5-carboximidamide, 2-[[[4-[[1-(1-iminoethyl)-4-piperidinyl]oxy]phenyl](methylsulfonyl)amino]methyl]-

There total 14 articles about Benzo[b]thiophene-5-carboximidamide, 2-[[[4-[[1-(1-iminoethyl)-4-piperidinyl]oxy]phenyl](methylsulfonyl)amino]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 2-[({4-[1-(1-imino-ethyl)-piperidin-4-yloxy]-phenyl}-methanesulfonyl-amino)-methyl]-benzo[b]thiophene-5-carboxamidine (364614-57-3)

Guidance literature:

Multi-step reaction with 8 steps

1.1: NaH / tetrahydrofuran

2.1: H₂ / 10 percent Pd/C / methanol / 760 Torr

3.1: pyridine

4.1: Cs₂CO₃ / dimethylformamide

5.1: NH₂OH / ethanol

6.1: acetic anhydride; acetic acid

6.2: H₂ / 10 percent Pd/C / methanol / 760 Torr

7.1: TFA / CH₂Cl₂

8.1: Et₃N / ethanol

With pyridine; hydrogen; hydroxylamine; acetic anhydride; sodium hydride; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00927-7

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 2-[({4-[1-(1-imino-ethyl)-piperidin-4-yloxy]-phenyl}-methanesulfonyl-amino)-methyl]-benzo[b]thiophene-5-carboxamidine (364614-57-3)

Guidance literature:

Multi-step reaction with 8 steps

1.1: NaH / tetrahydrofuran

2.1: H₂ / 10 percent Pd/C / methanol / 760 Torr

3.1: pyridine

4.1: Cs₂CO₃ / dimethylformamide

5.1: NH₂OH / ethanol

6.1: acetic anhydride; acetic acid

6.2: H₂ / 10 percent Pd/C / methanol / 760 Torr

7.1: TFA / CH₂Cl₂

8.1: Et₃N / ethanol

With pyridine; hydrogen; hydroxylamine; acetic anhydride; sodium hydride; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00927-7

Reference yield:

tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate (138227-62-0) → 2-[({4-[1-(1-imino-ethyl)-piperidin-4-yloxy]-phenyl}-methanesulfonyl-amino)-methyl]-benzo[b]thiophene-5-carboxamidine (364614-57-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: H₂ / 10 percent Pd/C / methanol / 760 Torr

2.1: pyridine

3.1: Cs₂CO₃ / dimethylformamide

4.1: NH₂OH / ethanol

5.1: acetic anhydride; acetic acid

5.2: H₂ / 10 percent Pd/C / methanol / 760 Torr

6.1: TFA / CH₂Cl₂

7.1: Et₃N / ethanol

With pyridine; hydrogen; hydroxylamine; acetic anhydride; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00927-7

upstream raw materials:

ethyl acetimidate hydrochloride

4-fluorobenzonitrile

2-(hydroxymethyl)benzo[b]thiophene-5-carbonitrile

4-fluoro-3-formylbenzonitrile

Refernces