Unii-928Q33Q049

Base Information

• Chemical Name: Unii-928Q33Q049
• CAS No.: 857402-63-2
• Molecular Formula: C₃₁H₄₅N₃O₈*ClH
• Molecular Weight: 624.175
• Mol file: 857402-63-2.mol

Synonyms:17-(Allylamino)-17-demethoxygeldanamycin;Retaspimycin hydrochloride [USAN];UNII-928Q33Q049;NSC-330507;Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propenylamino)-, monohydrochloride;17-Allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride;(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13,20,22-Trihydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-19-(prop-2-enylamino)-2-azabicyclo(16.3.1)docosa-1(21),4,6,10,18(22),19-hexen-9-yl carbamate hydrochloride;

Chemical Property of Unii-928Q33Q049

Chemical Property:

• PSA: 172.60000
• LogP: 6.09350
• Solubility.: ≥26.1 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥100 mg/mL in EtOH with ultrasonic

Purity/Quality:

98% ^*data from raw suppliers

Retaspimycinhydrochloride >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Unii-928Q33Q049

There total 1 articles about Unii-928Q33Q049 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

17-allylamino-17-demethoxygeldanamycin (75747-14-7) → retaspimycin hydrochloride (857402-63-2)

Guidance literature:

17-allylamino-17-demethoxygeldanamycin; With sodium dithionite; In dichloromethane; water; for 0.5h;

With hydrogenchloride; In 1,4-dioxane; dichloromethane; water; for 0.5h;

upstream raw materials:

17-allylamino-17-demethoxygeldanamycin

Refernces

• 1、 -. "Hydroquinone Ansamycin Formulations". Page/Page column 8-9. . Retrieved 2008/12/04.