3,3-Difluorocyclobutanemethanamine

Base Information

• Chemical Name: 3,3-Difluorocyclobutanemethanamine
• CAS No.: 1159882-59-3
• Molecular Formula: C5H9F2N
• Molecular Weight: 121.13
• Hs Code.: 2921309990
• Mol file: 1159882-59-3.mol

Synonyms:3,3-Difluorocyclobutanemethanamine;

Chemical Property of 3,3-Difluorocyclobutanemethanamine

Chemical Property:

• Boiling Point: 117.723 °C at 760 mmHg
• Flash Point: 19.932 °C
• PSA: 26.02000
• Density: 1.123 g/cm³
• LogP: 1.69070

Purity/Quality:

99% ^*data from raw suppliers

(3,3-Difluorocyclobutyl)methanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (3,3-Difluorocyclobutyl)methanamine is used as a reactant in the preparation of immunomodulators useful for treatment, prevention, and/or slowing the progression of viral diseases or disorders and cancer.

Technology Process of 3,3-Difluorocyclobutanemethanamine

There total 1 articles about 3,3-Difluorocyclobutanemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3-difluorocyclobutane-1-carbonitrile (86770-80-1) → 1-(3,3-difluorocyclobutyl)methanamine (1159882-59-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 25 ℃;

DOI:10.1021/jm300623u

Reference yield: 53.2%

1-(3,3-difluorocyclobutyl)methanamine (1159882-59-3) + 2-[(3,3-dimethyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)amino]-4-{[(1S)-2-hydroxy-1-phenylethyl]amino}pyrimidine-5-carboxylic acid → N-[(3,3-difluorocyclobutyl)methyl]-2-[(3,3-dimethyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)amino]-4-{[(1S)-2-hydroxy-1-phenylethyl]amino}pyrimidine-5-carboxamide

Guidance literature:

With N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridine-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield: 11.0%

1-(3,3-difluorocyclobutyl)methanamine (1159882-59-3) + 1-(isocyanomethyl)-4-(trifluoromethoxy)benzene (1029634-31-8) + o-carboxybenzaldehyde (119-67-5) → 2-((3,3-difluorocyclobutyl)methyl)-3-oxo-N-(4-(trifluoromethoxy)benzyl)isoindoline-1-carboxamide (1198160-27-8)

Guidance literature:

In methanol; at 20 ℃;

DOI:10.1021/jm300623u

upstream raw materials:

3,3-difluorocyclobutane-1-carbonitrile

Downstream raw materials:

2-((3,3-difluorocyclobutyl)methyl)-3-oxo-N-(4-(trifluoromethoxy)benzyl)isoindoline-1-carboxamide

benzyl 5-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-1-((3.3-difluorocyclobutyl)methyl)-2-methyl-1H-pyrrole-3-carboxylate

Refernces

• 1、 -. "ISOINDOLINE DERIVATIVES COMPRISING PHENYL GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS". Page/Page column 31. . Retrieved 2009/12/27.