7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone

Base Information

• Chemical Name: 7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone
• CAS No.: 205448-29-9
• Molecular Formula: C₁₇H₁₅NO₃
• Molecular Weight: 281.311
• Mol file: 205448-29-9.mol

Synonyms:7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone;7-Benzyloxy-6-methoxy-1H-quinolin-4-one

Chemical Property of 7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone

Chemical Property:

• Boiling Point: 460.0±45.0 °C(Predicted)
• PKA: 2.71±0.50(Predicted)
• PSA: 51.32000
• Density: 1.218
• LogP: 3.11570

Purity/Quality:

99%, ^*data from raw suppliers

7-(Benzyloxy)-6-methoxyquinolin-4(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone

There total 16 articles about 7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone (75665-73-5) + formic acid ethyl ester (109-94-4) → 6-methoxy-7-benzyloxy-4(1H)-quinolinone (205448-29-9,849217-23-8)

Guidance literature:

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone; With sodium methylate; In 1,2-dimethoxyethane; at 0 ℃; for 1h;

formic acid ethyl ester; In 1,2-dimethoxyethane; at 0 - 20 ℃;

Reference yield: 90.1%

ethyl 3-(3-benzyloxy-4-methoxyphenyl)iminopropionate → 7-benzyloxy-4-hydroxy-6-methoxyquinoline (205448-29-9,849217-23-8)

Guidance literature:

In diphenylether; at 180 ℃; for 6h; Temperature;

Reference yield: 82.0%

5-{[(3-(benzyloxy)-4-methoxyphenyl)amino]methylene}-2,2-dimethyl-1,3-dioxane-4,6- dione (205448-28-8) → 6-methoxy-7-benzyloxy-4(1H)-quinolinone (205448-29-9,849217-23-8)

Guidance literature:

In diphenylether; for 0.0833333h; Heating / reflux;

upstream raw materials:

5-{[(3-(benzyloxy)-4-methoxyphenyl)amino]methylene}-2,2-dimethyl-1,3-dioxane-4,6- dione

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone

formic acid ethyl ester

benzyl bromide

Downstream raw materials:

7-benzyloxy-4-chloro-6-methoxyquinoline hydrochloride

7-benzyloxy-4-(2-fluoro-4-nitro-phenoxy)-6-methyloxyquinoline

trifluoromethanesulfonic acid 7-benzyloxy-6-methoxy-quinolin-4-yl ester

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Refernces

• 1、 Chen, Tao,Fang, Wei-Rong,Huang, Wei,Li, Yun-Man,Liu, Peng-Fei,Zhuo, Lin-Sheng. "Discovery of 1,6-naphthyridinone-based MET kinase inhibitor bearing quinoline moiety as promising antitumor drug candidate". . . Retrieved 2020/02/29.
• 2、 -. "Quinoline or quinazoline derivatives as well as preparation method and application thereof". . . Retrieved 2017/04/11.