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Technology Process of Pyridone 6

Pyridone 6

Base Information Edit
  • Chemical Name:Pyridone 6
  • CAS No.:457081-03-7
  • Molecular Formula:C18H16FN3O
  • Molecular Weight:309.13
  • Hs Code.:
  • UNII:LDX3F0CCST
  • DSSTox Substance ID:DTXSID40420526
  • Nikkaji Number:J1.696.482D
  • Wikidata:Q27096425
  • NCI Thesaurus Code:C172200
  • Pharos Ligand ID:K2P152W58CCR
  • Metabolomics Workbench ID:149149
  • ChEMBL ID:CHEMBL21156
  • Mol file:457081-03-7.mol
Pyridone 6

Synonyms:2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one;pyridone 6

Suppliers and Price of Pyridone 6
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Pyridone6
  • 5mg
  • $ 285.00
  • Tocris
  • Pyridone6 ≥98%(HPLC)
  • 50
  • $ 802.00
  • Tocris
  • Pyridone6 ≥98%(HPLC)
  • 10
  • $ 191.00
  • Sigma-Aldrich
  • JAK Inhibitor I - CAS 457081-03-7 - CalbiochemJAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC = 15 nM), JAK2 (IC = 1 nM), JAK3 (Ki = 5 nM) and Tyk2 (IC = 1 nM).
  • 1mg
  • $ 200.00
  • Sigma-Aldrich
  • JAK Inhibitor I - CAS 457081-03-7 - CalbiochemJAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC = 15 nM), JAK2 (IC = 1 nM), JAK3 (Ki = 5 nM) and Tyk2 (IC = 1 nM).
  • 500ug
  • $ 124.00
  • Sigma-Aldrich
  • InSolutionJAKInhibitorI-CAS457081-03-7-Calbiochem TheInSolutionJAKInhibitorI,alsoreferencedunderCAS457081-03-7,controls
  • 500 μg
  • $ 119.32
  • Sigma-Aldrich
  • JAK Inhibitor I - CAS 457081-03-7 - Calbiochem JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC?? = 15 nM), JAK2 (IC?? = 1 nM), JAK3 (Ki = 5 nM) and Tyk2 (IC?? = 1 nM).
  • 500 μg
  • $ 140.60
  • Medical Isotopes, Inc.
  • Pyridone6
  • 10 mg
  • $ 2400.00
  • Matrix Scientific
  • 2-tert-Butyl-9-fluoro-3H-benzo[h]imidazo[4,5-f]isoquinolin-7(6H)-one 95%
  • 250mg
  • $ 5366.00
  • Matrix Scientific
  • 2-tert-Butyl-9-fluoro-3H-benzo[h]imidazo[4,5-f]isoquinolin-7(6H)-one 95%
  • 100mg
  • $ 2683.00
Total 44 raw suppliers
Chemical Property of Pyridone 6 Edit
Chemical Property:
  • Boiling Point:646.481 °C at 760 mmHg 
  • PKA:11.35±0.20(Predicted) 
  • Flash Point:344.78 °C 
  • PSA：61.80000 
  • Density:1.329 g/cm3 
  • LogP:4.40650 
  • Storage Temp.:-20C 
  • Solubility.:Soluble in DMSO (30 mg/ml) 
  • XLogP3:4
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:1
  • Exact Mass:309.12774030
  • Heavy Atom Count:23
  • Complexity:529
Purity/Quality:

99.0% *data from raw suppliers

Pyridone6 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC(C)(C)C1=NC2=C(N1)C3=C(C=C(C=C3)F)C4=C2C=CNC4=O
  • Recent ClinicalTrials:The Use of Synovial Biopsies in Predicting Response to Biologic Therapy in Rheumatoid Arthritis Patients
  • Description Pyridone 6 (457081-03-7) is a potent, ATP-competitive pan-JAK inhibitor. Inhibits 1, 2 and 3 (IC50=1, 5 and 15 nM respectively) as well as JAK family member Tyk2 (IC50=1 nM).1 Also tested against 21 other kinases with inhibition ranging from 130 nm to >10 mM. Inhibits IL2 and IL4-dependent proliferation of CTLL cells.1 Induces intermediate mesoderm differentiation from embryonic stem cells in a cocktail with LY-294002, CCG-1423 and retinoic acid.2 Potently inhibits STAT1, STAT5 and STAT6 phosphorylation and ameliorates allergic skin inflammation in a mouse model.3 Suppresses asthmatic responses in a mouse allergic asthma model.4
  • Uses Pyridone 6 is a ATP-competitive JAK inhibitor in clinical development for the treatment of myeloproliferative neoplasms and B cell acute lymphoblastic leukemia.

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