WZ3146

Base Information

• Chemical Name: WZ3146
• CAS No.: 1214265-56-1
• Molecular Formula: C24H25ClN6O2
• Molecular Weight: 464.955
• Mol file: 1214265-56-1.mol

Synonyms:WZ3146;

Chemical Property of WZ3146

Chemical Property:

• PKA: 12.78±0.70(Predicted)
• PSA: 86.11000
• Density: 1.319g/cm³
• LogP: 5.26760
• Solubility.: ≥23.25 mg/mL in DMSO with gentle warming

Purity/Quality:

98%,99%, ^*data from raw suppliers

WZ3146 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: WZ3146 is an irreversiblely inhibitor against EGFR T790M.

Technology Process of WZ3146

There total 6 articles about WZ3146 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-N-(4-(4-methylpiperazin-1-yl)phenyl)-4-(3-nitrophenoxy)pyrimidin-2-amine (1265527-54-5) → WZ3146 (1214265-56-1)

Guidance literature:

Multi-step reaction with 2 steps

1: platinum(IV) oxide; hydrogen / methanol

2: N-ethyl-N,N-diisopropylamine / dichloromethane

With platinum(IV) oxide; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2010.12.036

Reference yield:

2,5-dichloro-4-(3-nitrophenoxy)pyrimidine (76661-24-0) → WZ3146 (1214265-56-1)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / iso-butanol / 100 °C

2: platinum(IV) oxide; hydrogen / methanol

3: N-ethyl-N,N-diisopropylamine / dichloromethane

With platinum(IV) oxide; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; iso-butanol;

DOI:10.1016/j.bmcl.2010.12.036

Reference yield:

4-(4-Methyl-piperazino)-anilin (16153-81-4) → WZ3146 (1214265-56-1)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / iso-butanol / 100 °C

2: platinum(IV) oxide; hydrogen / methanol

3: N-ethyl-N,N-diisopropylamine / dichloromethane

With platinum(IV) oxide; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; iso-butanol;

DOI:10.1016/j.bmcl.2010.12.036

upstream raw materials:

5-chloro-N-(4-(4-methylpiperazin-1-yl)phenyl)-4-(3-nitrophenoxy)pyrimidin-2-amine

4-(3-aminophenoxy)-5-chloro-N-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine

acryloyl chloride

2,5-dichloro-4-(3-nitrophenoxy)pyrimidine

Refernces

• 1、 -. "EGFR INHIBITORS AND METHODS OF TREATING DISORDERS". Page/Page column 125. . Retrieved 2010/11/18.