2,3-Difluoro-6-nitroaniline

Base Information

• Chemical Name: 2,3-Difluoro-6-nitroaniline
• CAS No.: 211693-73-1
• Molecular Formula: C6H4F2N2O2
• Molecular Weight: 174.107
• Hs Code.: 2921420090
• European Community (EC) Number: 671-860-8
• DSSTox Substance ID: DTXSID20371784
• Wikidata: Q72463488
• Mol file: 211693-73-1.mol

Synonyms:2,3-Difluoro-6-nitroaniline;211693-73-1;2-Amino-3,4-difluoronitrobenzene;2,3-difluoro-6-nitrophenylamine;Benzenamine, 2,3-difluoro-6-nitro-;MFCD00233313;5,6-difluoro-2-nitroaniline;SCHEMBL938956;9H-Xanthen-9-one, 2-ethyl-;DTXSID20371784;DIPGYZSCGXBTEU-UHFFFAOYSA-N;2,3-Difluoro-6-nitro-phenylamine;TD1289;2,3-bis(fluoranyl)-6-nitro-aniline;AKOS009159119;AC-7299;AM84491;CS-W005072;BP-10711;DS-13249;SY005558;FT-0676368;EN300-84813;A809435;J-013895

Chemical Property of 2,3-Difluoro-6-nitroaniline

Chemical Property:

• Vapor Pressure: 0.00301mmHg at 25°C
• Refractive Index: 1.575
• Boiling Point: 284.2 °C at 760 mmHg
• PKA: -2.87±0.25(Predicted)
• Flash Point: 125.7 °C
• PSA: 71.84000
• Density: 1.554 g/cm³
• LogP: 2.55960
• Storage Temp.: Room temperature.
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 174.02408370
• Heavy Atom Count: 12
• Complexity: 185

Purity/Quality:

99% ^*data from raw suppliers

2,3-Difluoro-6-nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1[N+](=O)[O-])N)F)F

Technology Process of 2,3-Difluoro-6-nitroaniline

There total 2 articles about 2,3-Difluoro-6-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

2,3,4-trifluoronitrobenzene (771-69-7) → 2-amino-3,4-difluoronitro-benzene (211693-73-1)

Guidance literature:

With ammonium hydroxide; In ethanol; at 20 ℃; for 8h;

Reference yield: 84.0%

methanolic ammonia + 2,3,4-trifluoronitrobenzene (771-69-7) → 2-amino-3,4-difluoronitro-benzene (211693-73-1)

Guidance literature:

In ethyl acetate;

Reference yield: 100.0%

2-amino-3,4-difluoronitro-benzene (211693-73-1) + 5-trifluoromethyl-2,3-dihydro-1H-isoindole (342638-03-3) → 2-fluoro-6-nitro-3-(5-(trifluoromethyl)isoindolin-2-yl)aniline

Guidance literature:

With iodine; triethylamine; In dimethyl sulfoxide; at 120 ℃; for 24h;

upstream raw materials:

2,3,4-trifluoronitrobenzene

Downstream raw materials:

3-amino-2-fluoro-4-nitrophenol

4-bromo-2,3-difluoro-6-nitroaniline

2-Fluoro-3-(4-methyl-piperazin-1-yl)-6-nitro-phenylamine

2-fluoro-3-(isopropylsulphanyl)-6-nitroaniline

Refernces

• 1、 -. "Fluorinated 2-Amino-4-(Benzylamino)Phenylcarbamate Derivatives". Paragraph 0135; 0136. . Retrieved 2013/11/06.
• 2、 -. "Benzimidazole derivatives for the treatment of viral infections". . . Retrieved 2008/06/13.