Ralimetinib Mesylate

Base Information

• Chemical Name: Ralimetinib Mesylate
• CAS No.: 862507-23-1
• Molecular Formula: CH₄O₃S*C₂₄H₂₉FN₆
• Molecular Weight: 516.64
• Hs Code.: 2933998090
• UNII: QUW7B71FO9
• ChEMBL ID: CHEMBL2364627
• DSSTox Substance ID: DTXSID60235457
• NCI Thesaurus Code: C105853
• Wikidata: Q27287506
• Mol file: 862507-23-1.mol

Synonyms:3-(2,2-Dimethylpropyl)-5-(4-(4-fluorophenyl)-2-(2-methyl-2-propanyl)-1H-imidazol-5-yl)-3H-imidazo(4,5-b)pyridin-2-amine;3H-Imidazo(4,5-b)pyridin-2-amine, 5-(2-(1,1-dimethylethyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)-3-(2,2-dimethylpropyl)-;LY2228820;LY2228820 dimesylate;ralimetinib

Chemical Property of Ralimetinib Mesylate

Chemical Property:

• Boiling Point: 634.4 °C at 760 mmHg
• Flash Point: 337.5 °C
• PSA: 211.64000
• LogP: 6.65300
• Solubility.: ≥30.65 mg/mL in DMSO; ≥45 mg/mL in H2O with ultrasonic; ≥9.9 mg/mL in EtOH with ultrasonic
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 5
• Exact Mass: 612.22000343
• Heavy Atom Count: 41
• Complexity: 701

Purity/Quality:

99% ^*data from raw suppliers

LY2228820 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O
• Recent ClinicalTrials: A Study of LY2228820 in Participants With Advanced Cancer
• Recent EU Clinical Trials: A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2 Study of LY2228820, a p38MAPK Inhibitor, plus Gemcitabine and Carboplatin versus Gemcitabine and Carboplatin for Women with Platinum-Sensitive Ovarian Cancer
• Uses: LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity. LY2228820 significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib (B675700) and by reducing osteoskeletal events.

Technology Process of Ralimetinib Mesylate

There total 1 articles about Ralimetinib Mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 5-[2-tert-butyl-5-(4-fluorophenyl)-3H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-ylamine methanesulfonate (862507-23-1)

Guidance literature:

Refernces