WZ8040

Base Information

• Chemical Name: WZ8040
• CAS No.: 1214265-57-2
• Molecular Formula: C24H25ClN6OS
• Molecular Weight: 481.021
• Mol file: 1214265-57-2.mol

Synonyms:N-[3-[5-Chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]sulfanylphenyl]prop-2-enamide;

Chemical Property of WZ8040

Chemical Property:

• PKA: 12.94±0.70(Predicted)
• PSA: 102.18000
• Density: 1.374 g/cm³
• LogP: 5.62650
• Solubility.: ≥24.05 mg/mL in DMSO; insoluble in H2O; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic

Purity/Quality:

98%,99%, ^*data from raw suppliers

WZ8040 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: WZ8040 is an inhibitor of mutant EGF receptors (EGFRs) with IC50 values ranging from 2 to 306 nM in Ba/F3 cells. It is selective for EGFR mutants, including the EGFRDel E746_A750 and EGFRL858R mutations conferring gefitinib sensitivity and the EGFRDel E746_A750/T790M mutation conferring gefitinib resistance (IC50s = 2, 6, and 6 nM in Ba/F3 cells), over wild-type EGFR (IC50 = 1,820 nM in HN11 cells) but also inhibits ERBB2Ins G776V,C and wild-type ERBB2 (IC50s = 20 and 32 nM, respectively, in Ba/F3 cells). WZ8040 inhibits proliferation of PC-9 cells harboring the EGFRDel E746_A750 mutation and gefitinib-resistant PC-9 GR cells harboring the EGFRT790M resistant allele (EC50s = 6 and 8 nM, respectively).
• Uses: WZ8040 is an irreversiblely EGFR T790M inhibitor (IC50<10nM).

Technology Process of WZ8040

There total 1 articles about WZ8040 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ WZ8040 (1214265-57-2)

Guidance literature:

Refernces