4-Methyl-2-[[2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]acetyl]amino]pentanoic acid

Base Information

• Chemical Name: 4-Methyl-2-[[2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]acetyl]amino]pentanoic acid
• CAS No.: 13347-77-8
• Molecular Formula: C18H25N3O6
• Molecular Weight: 379.413
• Hs Code.: 2934999090
• NSC Number: 169164
• DSSTox Substance ID: DTXSID90305117
• Mol file: 13347-77-8.mol

Synonyms:Z-Gly-Gly-Leu;13347-77-8;4-methyl-2-[[2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]acetyl]amino]pentanoic acid;NSC169164;DTXSID90305117;(2S)-4-methyl-2-[[2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]acetyl]amino]pentanoic acid;NSC-169164;SB44546;FT-0697571;A851125

Chemical Property of 4-Methyl-2-[[2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]acetyl]amino]pentanoic acid

Chemical Property:

• Vapor Pressure: 3.06E-21mmHg at 25°C
• Refractive Index: 1.539
• Boiling Point: 711.4 °C at 760 mmHg
• Flash Point: 384 °C
• PSA: 133.83000
• Density: 1.236 g/cm³
• LogP: 1.81720
• Storage Temp.: -15°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 11
• Exact Mass: 379.17433553
• Heavy Atom Count: 27
• Complexity: 517

Purity/Quality:

99% ^*data from raw suppliers

Z-Gly-Gly-Leu-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)CC(C(=O)O)NC(=O)CNC(=O)CNC(=O)OCC1=CC=CC=C1

Technology Process of 4-Methyl-2-[[2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]acetyl]amino]pentanoic acid

There total 6 articles about 4-Methyl-2-[[2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]acetyl]amino]pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Gly-Gly-Leu-pNA (53046-98-3) → Cbz-Gly-Gly-L-Leu-OH (13347-77-8) + 4-nitro-aniline (100-01-6,104810-17-5)

Guidance literature:

With Cudrania protease; In dimethyl sulfoxide; at 25 ℃; pH=7.0; Kinetics;

DOI:10.1271/bbb.64.623

Reference yield:

7-(Nα-benzyloxycarbonyl-glycylglycyl-L-leucyl)amino-4-methylcoumarin (97792-39-7) → 7-amino-4-methylcoumarin. (26093-31-2) + Cbz-Gly-Gly-L-Leu-OH (13347-77-8)

Guidance literature:

at 37 ℃; Rate constant; enzyme assay: 50 mM Tris-HCl buffer, pH=8.2, DMF (7.5percent);

DOI:10.1248/cpb.33.1721

Reference yield:

CbzGlyGly (2566-19-0) → Cbz-Gly-Gly-L-Leu-OH (13347-77-8)

Guidance literature:

With chloroformic acid ethyl ester; triethylamine; anschliessend Behandeln mit L-Leucin und wss. NaOH;

upstream raw materials:

CbzGlyGly

N-[N-(N-benzyloxycarbonyl-glycyl)-glycyl]-L-leucine methyl ester

Z-Gly-Gly-Leu-NH₂

7-(N^α-benzyloxycarbonyl-glycylglycyl-L-leucyl)amino-4-methylcoumarin

Refernces

• 1、 Steinke, Doerte,Kula, Maria-Regina. "Selektive Desamidierung von Peptidamiden". . p. 1204 - 1206. Retrieved 2007/10/02.