2,2,2-Trifluoro-1-(4-methoxyphenyl)ethyl Bromide

Base Information

• Chemical Name: 2,2,2-Trifluoro-1-(4-methoxyphenyl)ethyl Bromide
• CAS No.: 104395-39-3
• Molecular Formula: C9H8BrF3O
• Molecular Weight: 269.061
• Mol file: 104395-39-3.mol

Synonyms:2,2,2-Trifluoro-1-(4-methoxyphenyl)ethyl Bromide;

Chemical Property of 2,2,2-Trifluoro-1-(4-methoxyphenyl)ethyl Bromide

Chemical Property:

• PSA: 9.23000
• LogP: 3.69350

Purity/Quality:

99% ^*data from raw suppliers

2,2,2-Trifluoro-1-(4-methoxyphenyl)ethylBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2,2,2-Trifluoro-1-(4-methoxyphenyl)ethyl Bromide is a useful compound in pesticidal compositions.

Technology Process of 2,2,2-Trifluoro-1-(4-methoxyphenyl)ethyl Bromide

There total 5 articles about 2,2,2-Trifluoro-1-(4-methoxyphenyl)ethyl Bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

→ 1-(1-bromo-2,2,2-trifluoroethyl)-4-methoxybenzene (104395-39-3)

Guidance literature:

Reference yield: 75.0%

2,2,2-trifluoro-1-(4-methoxyphenyl)ethanol (17556-42-2,80446-58-8,80446-59-9,1737-27-5) → 1-(1-bromo-2,2,2-trifluoroethyl)-4-methoxybenzene (104395-39-3)

Guidance literature:

With triphenyl phosphite; N-Bromosuccinimide; In 1,2-dichloro-ethane; at -10 - 20 ℃; for 4h;

DOI:10.1021/acs.orglett.0c03673

Reference yield: 51.0%

2,2,2-trifluorodiazoethane (371-67-5) + potassium 4-(methoxy)phenyltrifluoroborate → 1-(1-bromo-2,2,2-trifluoroethyl)-4-methoxybenzene (104395-39-3)

Guidance literature:

2,2,2-trifluorodiazoethane; potassium 4-(methoxy)phenyltrifluoroborate; With p-tolyltrichlorosilane; In toluene; at 40 ℃; Inert atmosphere;

With N-Bromosuccinimide; In toluene; acetonitrile; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1002/anie.201308036

upstream raw materials:

Methanesulfonic acid 2,2,2-trifluoro-1-(4-methoxy-phenyl)-ethyl ester

2,2,2-trifluoro-1-(4-methoxyphenyl)ethanol

2,2,2-trifluorodiazoethane

4-methoxy-benzaldehyde

Downstream raw materials:

4,4'-(2,2,2-trifluoroethane-1,1-diyl)bis(methoxybenzene)

1-methoxy-4-(2,2,2-trifluoroethyl)benzene

N-(Methoxyethyl)-1-(4-methoxyphenyl)-2,2,2-trifluoroethylamine

N-(Methoxyethyl)-1-(4-((methoxyethyl)amino)phenyl)-2,2,2-trifluoroethylamine

Refernces

• 1、 Gu, Yucheng,Hu, Jinbo,Kuang, Cuiwen,Ni, Chuanfa. "Photoredox-Catalyzed Ring-Opening Addition Reaction between Benzyl Bromides and Cyclic Ethers". . . Retrieved 2021/12/24.
• 2、 Gu, Yucheng,Hu, Jinbo,Kuang, Cuiwen,Ni, Chuanfa,Xie, Qiqiang,Zhou, Xin. "Generation of Carbocations under Photoredox Catalysis: Electrophilic Aromatic Substitution with 1-Fluoroalkylbenzyl Bromides". supporting information. . Retrieved 2020/11/13.