Z(OMe)-Thr-Lys(Z)-Asp(OBzl)-Leu-Lys(Z)-NHNH-Troc

Base Information

• Chemical Name: Z(OMe)-Thr-Lys(Z)-Asp(OBzl)-Leu-Lys(Z)-NHNH-Troc
• CAS No.: 83550-60-1
• Molecular Formula: C₆₁H₇₈Cl₃N₉O₁₇
• Molecular Weight: 1315.7
• Mol file: 83550-60-1.mol

Synonyms:

Chemical Property of Z(OMe)-Thr-Lys(Z)-Asp(OBzl)-Leu-Lys(Z)-NHNH-Troc

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z(OMe)-Thr-Lys(Z)-Asp(OBzl)-Leu-Lys(Z)-NHNH-Troc

There total 5 articles about Z(OMe)-Thr-Lys(Z)-Asp(OBzl)-Leu-Lys(Z)-NHNH-Troc which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z(OMe)-Lys(Z)-OH (42533-12-0) → Z(OMe)-Thr-Lys(Z)-Asp(OBzl)-Leu-Lys(Z)-NHNH-Troc (83550-60-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 97 percent / N-hydroxybenzotriazole, 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide / tetrahydrofuran / 16 h / 4 °C

2: 1.) TFA, anisole 2.) N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, N-methylmorpholine / 1.) room temp., 30 min 2.) THF, DMF, 16 h, 4 deg C

3: 1.) TFA, anisole 2.) N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, N-methylmorpholine / 1.) room temp., 30 min 2.) THF, DMF, 16 h, 4 deg C

4: 1.) TFA, anisole 2.) N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, N-methylmorpholine / 1.) room temp., 30 min 2.) THF, DMF, 16 h, 4 deg C

5: 1.) TFA, anisole 2.) N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, N-methylmorpholine / 1.) room temp., 30 min 2.) THF, DMF, 16 h, 4 deg C

With 4-methyl-morpholine; benzotriazol-1-ol; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; trifluoroacetic acid; In tetrahydrofuran;

DOI:10.1248/cpb.30.1776

Reference yield:

Z(OMe)-Leu-Lys(Z)-NHNH-Troc (83550-57-6) → Z(OMe)-Thr-Lys(Z)-Asp(OBzl)-Leu-Lys(Z)-NHNH-Troc (83550-60-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) TFA, anisole 2.) N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, N-methylmorpholine / 1.) room temp., 30 min 2.) THF, DMF, 16 h, 4 deg C

2: 1.) TFA, anisole 2.) N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, N-methylmorpholine / 1.) room temp., 30 min 2.) THF, DMF, 16 h, 4 deg C

3: 1.) TFA, anisole 2.) N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, N-methylmorpholine / 1.) room temp., 30 min 2.) THF, DMF, 16 h, 4 deg C

With 4-methyl-morpholine; methoxybenzene; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; trifluoroacetic acid;

DOI:10.1248/cpb.30.1776

Reference yield:

Z(OMe)-Asp(OBzl)-Leu-Lys(Z)-NHNH-Troc (83550-58-7) → Z(OMe)-Thr-Lys(Z)-Asp(OBzl)-Leu-Lys(Z)-NHNH-Troc (83550-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) TFA, anisole 2.) N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, N-methylmorpholine / 1.) room temp., 30 min 2.) THF, DMF, 16 h, 4 deg C

2: 1.) TFA, anisole 2.) N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, N-methylmorpholine / 1.) room temp., 30 min 2.) THF, DMF, 16 h, 4 deg C

With 4-methyl-morpholine; methoxybenzene; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; trifluoroacetic acid;

DOI:10.1248/cpb.30.1776

upstream raw materials:

methoxybenzyloxycarbonyl-Thr

Z(OMe)-Lys(Z)-Asp(OBzl)-Leu-Lys(Z)-NHNH-Troc

Z(OMe)-Lys(Z)-OH

Z(OMe)-Leu-Lys(Z)-NHNH-Troc

Downstream raw materials:

Z(OMe)-Thr-Thr-Lys(Z)-Asp(OBzl)-Leu-Lys(Z)-NHNH-Troc

Refernces