2-aminocyclohexanone hydrochloride

Base Information

• Chemical Name: 2-aminocyclohexanone hydrochloride
• CAS No.: 6946-05-0
• Molecular Formula: C6H12ClNO
• Molecular Weight: 149.62
• Hs Code.: 2922399090
• Mol file: 6946-05-0.mol

Synonyms:Cyclohexanone,2-amino-, hydrochloride (6CI,7CI,8CI,9CI);2-Aminocyclohexanone hydrochloride;NSC 53144;

Chemical Property of 2-aminocyclohexanone hydrochloride

Chemical Property:

• Vapor Pressure: 0.16mmHg at 25°C
• Melting Point: 157-158 °C (decomp)
• Refractive Index: 1.479
• Boiling Point: 213.9 °C at 760 mmHg
• Flash Point: 83.2 °C
• PSA: 43.09000
• Density: 1.023g/cm³
• LogP: 1.95910
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

2-Aminocyclohexanonehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22-41-51/53

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-aminocyclohexanone hydrochloride

There total 4 articles about 2-aminocyclohexanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 2-aminocyclohexanone hydrochloride (6946-05-0)

Guidance literature:

cyclohexanone; With Benzophenone imine; 1-methoxy-3,3-dimethyl-1,2-benziodoxole; at 75 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; In methanol; water; at 45 ℃; for 24h; Inert atmosphere;

DOI:10.1002/chem.202102627

Reference yield: 79.0%

2,4,5,6,7,7a-Hexahydro-1H-benzimidazole-2-spiro-1'-cyclohexane (171974-66-6) → 2-aminocyclohexanone hydrochloride (6946-05-0)

Guidance literature:

With hydrogenchloride; at 40 ℃;

DOI:10.1021/jo00126a027

Reference yield: 61.0%

2-nitrocyclohexanone (4883-67-4) → 2-aminocyclohexanone hydrochloride (6946-05-0)

Guidance literature:

With hydrogen; sulfided platinum on carbon; In hydrogenchloride; ethanol; at 50 ℃; for 6h; under 760 Torr;

DOI:10.1016/S0040-4039(00)85319-8

upstream raw materials:

cyclohexylamine

2-nitrocyclohexanone

2,4,5,6,7,7a-Hexahydro-1H-benzimidazole-2-spiro-1'-cyclohexane

cyclohexanone

Downstream raw materials:

4,5,6,7-tetrahydro-3H-benzoxazol-2-one

1,3,4,5,6,7-hexahydro-benzoimidazole-2-thione

2,3,4,5,6,7-Hexahydro-1H-benzimidazol-2-on

1,2,3,4,6,7,8,9-octahydrophenazine

Refernces

• 1、 -. "6-SUBSTITUTED- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS". Page/Page column 70-71. . Retrieved 2008/06/13.
• 2、 Tamura, Rui,Oda, Daihei,Kurokawa, Hiroshi. "SYNTHESIS OF α-AMINO KETONE HYDROCHLORIDES VIA CHEMOSELECTIVE HYDROGENATION OF α-NITRO KETONES". . p. 5759 - 5762. Retrieved 2007/10/02.