2-Acetamido-7-amino-1-hydroxymitosen

Base Information

• Chemical Name: 2-Acetamido-7-amino-1-hydroxymitosen
• CAS No.: 54911-22-7
• Molecular Formula: C₁₆H₁₈N₄O₆
• Molecular Weight: 362.342
• Mol file: 54911-22-7.mol

Synonyms:

Chemical Property of 2-Acetamido-7-amino-1-hydroxymitosen

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Acetamido-7-amino-1-hydroxymitosen

There total 4 articles about 2-Acetamido-7-amino-1-hydroxymitosen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

mitomycin C (50-07-7) → cis-1-hydroxy-2-acetamido-7-aminomitosene (54911-22-7) + trans-1-hydroxy-2,7-diaminomitosene (99745-88-7,78655-54-6) + 2β,7-Diamino-1β-hydroxymitosene (98462-75-0,78655-54-6) + 2,7-Diaminomitosene (92695-32-4)

Guidance literature:

With Tris-HOAc-buffer pH 5.50; 4-methoxyphenylhydrazine hydrochloride; In water; for 48h; Mechanism; Ambient temperature; other substrates, also with D₂O;

DOI:10.1021/jo00032a037

Reference yield:

→ 2-Acetamido-7-amino-1-hydroxymitosen (1101-58-2,54911-22-7,55253-24-2)

Guidance literature:

cis-2-Acetamido-1-acetoxy-7-aminomitosen (in Me.), NH4OH (Siedetemp.);

DOI:10.1021/jm00237a020

Reference yield:

mitomycin C (50-07-7) + N,N-Dimethylhydrazine (57-14-7) → cis-1-hydroxy-2-acetamido-7-aminomitosene (54911-22-7) + trans-1-hydroxy-2,7-diaminomitosene (99745-88-7,78655-54-6) + 2β,7-Diamino-1β-hydroxymitosene (98462-75-0,78655-54-6) + Carbamic acid (1R,2S)-2,7-diamino-1-(N',N'-dimethyl-hydrazino)-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-9-ylmethyl ester + N-((1R,2S)-2,7-Diamino-9-carbamoyloxymethyl-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl)-N,N-dimethyl-hydrazinium; hydroxide + N-((1S,2S)-2,7-Diamino-9-carbamoyloxymethyl-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl)-N,N-dimethyl-hydrazinium; hydroxide

Guidance literature:

With tris-acetic acid buffer; for 14h; Product distribution; var. hydrazines;

DOI:10.1021/ja00239a051

upstream raw materials:

mitomycin C

N,N-Dimethylhydrazine

4-Methoxyphenylhydrazine

Refernces

• 1、 Russell, David J.,Kohn, Harold. "DEVELOPMENT OF A HYDRAZINE-MEDIATED SYSTEM FOR THE REDUCTIVE ACTIVATION OF MITOMYCIN C". . p. 223 - 227. Retrieved 2007/10/02.