(cyclobutylmethyl)benzene

Base Information

• Chemical Name: (cyclobutylmethyl)benzene
• CAS No.: 5244-88-2
• Molecular Formula: C11H14
• Molecular Weight: 146.232
• Mol file: 5244-88-2.mol

Synonyms:Methane,cyclobutylphenyl- (7CI,8CI); (Cyclobutylmethyl)benzene; Benzylcyclobutane;Cyclobutane, (phenylmethyl)-; Cyclobutylphenylmethane

Chemical Property of (cyclobutylmethyl)benzene

Chemical Property:

• Vapor Pressure: 0.248mmHg at 25°C
• Boiling Point: 212.7°C at 760 mmHg
• Flash Point: 73.9°C
• PSA: 52.60000
• Density: 0.979g/cm³
• LogP: 3.18930

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (cyclobutylmethyl)benzene

There total 10 articles about (cyclobutylmethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-cyclobutyl-1-phenyl-methanone (5407-98-7) → (1-phenylmethylene)cyclobutane (5244-88-2)

Guidance literature:

With potassium fluoride; 4-chloromethoxybenzene; palladium diacetate; In tetrahydrofuran; water; at 20 ℃; for 1h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ol102757v

Reference yield: 83.0%

1-cyclobutyl-1-phenyl-methanone (5407-98-7) → (1-phenylmethylene)cyclobutane (5244-88-2) + rac-(cyclobutyl)(phenyl)methanol (4397-00-6)

Guidance literature:

With potassium fluoride; palladium diacetate; chlorobenzene; In tetrahydrofuran; water; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol102757v

Reference yield: 75.0%

ethylmagnesium bromide (925-90-6) + (Z)-3-phenyl-1-propenyl N,n-diisopropylcarbamate (678150-52-2) → (1-phenylmethylene)cyclobutane (5244-88-2)

Guidance literature:

ethylmagnesium bromide; With zirconocene dichloride; In diethyl ether; at -78 - 0 ℃;

(Z)-3-phenyl-1-propenyl N,n-diisopropylcarbamate; In diethyl ether; at -78 - 20 ℃;

With hydrogenchloride; water; In diethyl ether;

DOI:10.1002/adsc.200800719

upstream raw materials:

1-cyclobutyl-1-phenyl-methanone

(+/-)-cyclobutyl(phenyl)methanamine

cyclobutyl-phenyl ketone oxime

N,N-Dimethyl-α-phenyl-cyclobutyl-methylamin

Downstream raw materials:

(1-bromo-1-phenylmethylene)cyclobutane

Refernces

• 1、 Rahaim, Ronald J.,Maleczka, Robert E.. "C-O hydrogenolysis catalyzed by Pd-PMHS nanoparticles in the company of chloroarenes". supporting information; experimental part. p. 584 - 587. Retrieved 2011/04/23.
• 2、 Di Vona, Maria Luisa,Luchetti, Luciana,Rosnati, Vittorio. "Zinc-promoted reactions. 8. The effect of ring strain in the reduction of 1,2-dibenzoylcycloalkanes". . p. 2949 - 2954. Retrieved 2007/10/02.