2-methyl-6-(trifluoromethyl)nicotinonitrile

Base Information

• Chemical Name: 2-methyl-6-(trifluoromethyl)nicotinonitrile
• CAS No.: 402479-93-0
• Molecular Formula: C₈H₅F₃N₂
• Molecular Weight: 186.136
• Hs Code.: 2933399990
• Mol file: 402479-93-0.mol

Synonyms:

Chemical Property of 2-methyl-6-(trifluoromethyl)nicotinonitrile

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-6-(trifluoromethyl)nicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-6-(trifluoromethyl)nicotinonitrile

There total 1 articles about 2-methyl-6-(trifluoromethyl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

(E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one (59938-06-6) + (E)-3-aminocrotononitrile (763-33-7) → 2-methyl-6-(trifluoromethyl)nicotinonitrile (402479-93-0)

Guidance literature:

In acetonitrile; at 80 ℃; for 20h;

Reference yield: 79.0%

2-methyl-6-(trifluoromethyl)nicotinonitrile (402479-93-0) → 2-methyl-6-(trifluoromethyl)pyridine-3-carboxylic acid (261635-93-2)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 100 ℃; for 1h;

Reference yield:

2-methyl-6-(trifluoromethyl)nicotinonitrile (402479-93-0) → O-ethyl S-2-methyl-6-(trifluoromethyl)pyridin-3-yl carbonodithioate + 2-methyl-6-(trifluoromethyl)pyridin-3-thiol

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / water; ethanol / 1 h / 100 °C

2.1: diphenyl phosphoryl azide; triethylamine / toluene / 2 h / 70 - 100 °C

3.1: ammonium formate; palladium 10% on activated carbon / ethanol / 0.67 h / 100 °C

4.1: hydrogenchloride; sodium nitrite / water / 2 h / 0 °C

4.2: 0.25 h / 65 °C

With hydrogenchloride; diphenyl phosphoryl azide; palladium 10% on activated carbon; ammonium formate; triethylamine; sodium hydroxide; sodium nitrite; In ethanol; water; toluene;

upstream raw materials:

(E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one

(E)-3-aminocrotononitrile

Downstream raw materials:

2-methyl-6-(trifluoromethyl)pyridine-3-carboxylic acid

Refernces