Technology Process of methyl (2Z)-2-(cyclohexyl(dimethyl(phenyl)silyl)methylene)pent-4-enoate
There total 3 articles about methyl (2Z)-2-(cyclohexyl(dimethyl(phenyl)silyl)methylene)pent-4-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
allyl methyl carbonate;
With
palladium diacetate; triphenylphosphine;
In
dichloromethane;
at 20 ℃;
for 0.0833333h;
Inert atmosphere;
Schlenk technique;
cyclohexylpropynoic acid methyl ester; dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane;
With
potassium tert-butylate; triphenylphosphine; copper(l) chloride;
In
dichloromethane;
at 45 ℃;
for 24h;
diastereoselective reaction;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/chem.201304284
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1.33 h / -78 °C / Inert atmosphere; Schlenk technique
1.2: 16 h / -78 - 20 °C / Inert atmosphere; Schlenk technique
2.1: palladium diacetate; triphenylphosphine / dichloromethane / 0.08 h / 20 °C / Inert atmosphere; Schlenk technique
2.2: 24 h / 45 °C / Inert atmosphere; Schlenk technique
With
n-butyllithium; palladium diacetate; triphenylphosphine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/chem.201304284
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium / mineral oil; tetrahydrofuran / 24 h / 0 °C / Inert atmosphere; Schlenk technique
1.2: 24 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
2.1: palladium diacetate; triphenylphosphine / dichloromethane / 0.08 h / 20 °C / Inert atmosphere; Schlenk technique
2.2: 24 h / 45 °C / Inert atmosphere; Schlenk technique
With
palladium diacetate; lithium; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1002/chem.201304284
