3-(4-Chlorophenyl)propan-1-ol

Base Information

• Chemical Name: 3-(4-Chlorophenyl)propan-1-ol
• CAS No.: 6282-88-8
• Molecular Formula: C9H11ClO
• Molecular Weight: 170.639
• Hs Code.: 2906299090
• Mol file: 6282-88-8.mol

Synonyms:3-(4-Chlorophenyl)propanol 95%;

Chemical Property of 3-(4-Chlorophenyl)propan-1-ol

Chemical Property:

• Appearance/Colour: Colorless liquid
• Vapor Pressure: 0.00331mmHg at 25°C
• Refractive Index: 1.545
• Boiling Point: 270.7 °C at 760 mmHg
• PKA: 15.03±0.10(Predicted)
• Flash Point: 117.5 °C
• PSA: 20.23000
• Density: 1.151 g/cm³
• LogP: 2.26490
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(4-Chlorophenyl)propan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-36/37/39-24/25-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(4-Chlorophenyl)propan-1-ol is used in preparation of 2-Oxo-2H-chromene-3-carboxylic Acid Amide derivatives as Aldo-Keto reductase inhibitors.

Technology Process of 3-(4-Chlorophenyl)propan-1-ol

There total 26 articles about 3-(4-Chlorophenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

p-chlorocinnamic acid (1615-02-7,940-62-5) → 3-(p-chlorophenyl)propanol (6282-88-8)

Guidance literature:

p-chlorocinnamic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; for 12h; Inert atmosphere; Cooling with ice; Reflux;

With hydrogenchloride; water; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

Reference yield: 97.0%

3-(4-chlorophenyl)propanoic acid (2019-34-3) → 3-(p-chlorophenyl)propanol (6282-88-8)

Guidance literature:

3-(4-chlorophenyl)propanoic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With Rochelle's salt; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 96.0%

4-chlorocinnamaldehyde (1075-77-0) → 3-(p-chlorophenyl)propanol (6282-88-8)

Guidance literature:

With chlorine[2-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxypyridine](pentamethylcyclopentadienyl)iridium(III) chloride; sodium formate; In water; at 80 ℃; for 0.5h; chemoselective reaction; Schlenk technique;

DOI:10.1021/acs.organomet.9b00353

upstream raw materials:

ethyl 3-(4-chlorophenyl)propanoate

4-vinylbenzyl chloride

carbon monoxide

oxirane

Downstream raw materials:

3-(4-chlorophenyl)propyl 5-amino-2-hydroxybenzoate

3-(4-chlorophenyl)propane-1-thiol

Refernces

• 1、 Nouaille, Augustin,Pannecoucke, Xavier,Poisson, Thomas,Couve-Bonnaire, Samuel. "Access to Trisubstituted Fluoroalkenes by Ruthenium-Catalyzed Cross-Metathesis". supporting information. p. 2140 - 2147. Retrieved 2021/03/06.
• 2、 Chen, Xiao-Chao,Gao, Han,Liu, Lei,Liu, Ye,Lu, Yong,Xia, Fei,Yang, Shu-Qing. "Ir-catalyzed tandem hydroformylation-transfer hydrogenation of olefins with (trans-/cis-)formic acid as hydrogen source in presence of 1,10-phenanthroline". . p. 183 - 193. Retrieved 2020/04/08.