Technology Process of Tamoxifen-SAHA Conjugate
There total 5 articles about Tamoxifen-SAHA Conjugate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: chloro-trimethyl-silane; dmap; pyridine
2: triethylamine / dichloromethane
3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4 h / 80 °C
4: hydroxylamine; potassium cyanide / tetrahydrofuran; methanol; water / 48 h
With
pyridine; dmap; potassium cyanide; chloro-trimethyl-silane; hydroxylamine; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jm400467w
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane
2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4 h / 80 °C
3: hydroxylamine; potassium cyanide / tetrahydrofuran; methanol; water / 48 h
With
potassium cyanide; hydroxylamine; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jm400467w
- Guidance literature:
-
Multi-step reaction with 4 steps
1: chloro-trimethyl-silane; dmap; pyridine
2: triethylamine / dichloromethane
3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4 h / 80 °C
4: hydroxylamine; potassium cyanide / tetrahydrofuran; methanol; water / 48 h
With
pyridine; dmap; potassium cyanide; chloro-trimethyl-silane; hydroxylamine; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jm400467w
