1-(4-Chlorophenyl)-2-fluoroethanone

Base Information

• Chemical Name: 1-(4-Chlorophenyl)-2-fluoroethanone
• CAS No.: 329-78-2
• Molecular Formula: C8H6ClFO
• Molecular Weight: 172.586
• Hs Code.: 2914700090
• Mol file: 329-78-2.mol

Synonyms:Acetophenone,4'-chloro-2-fluoro- (6CI,7CI,8CI);NSC 265872;

Chemical Property of 1-(4-Chlorophenyl)-2-fluoroethanone

Chemical Property:

• Appearance/Colour: light yellow or yellow crystal
• Melting Point: 54 °C
• Boiling Point: 260.3 °C at 760 mmHg
• Flash Point: 111.2 °C
• PSA: 17.07000
• Density: 1.247 g/cm³
• LogP: 2.49220
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-chlorophenyl)-2-fluoroethanone ^*data from reagent suppliers

Safty Information:

• Statements: 34-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Chlorophenyl)-2-fluoroethanone

There total 19 articles about 1-(4-Chlorophenyl)-2-fluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-(1-(4-chlorophenyl)-2-fluoroethylidene)isopropylamine (914801-65-3) → 1-(4-chlorophenyl)-2-fluoroethan-1-one (329-78-2)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/ol061720z

Reference yield: 88.0%

C15H10ClF5N2O2S → 1-(4-chlorophenyl)-2-fluoroethan-1-one (329-78-2)

Guidance literature:

With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; water; cesium fluoride; In N,N-dimethyl acetamide; at 40 ℃; for 18h; Reagent/catalyst; Solvent; chemoselective reaction; Sealed tube; Glovebox; Inert atmosphere;

DOI:10.1002/anie.202116190

Reference yield: 83.0%

1-(1-azidovinyl)-4-chlorobenzene → 1-(4-chlorophenyl)-2-fluoroethan-1-one (329-78-2)

Guidance literature:

With water; sodium hydrogencarbonate; Selectfluor; In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1021/acs.orglett.6b01691

upstream raw materials:

monofluoroacetyl chloride

chlorobenzene

[(E)-1-(4-Chloro-phenyl)-2-fluoro-vinyloxy]-trimethyl-silane

N-(1-(4-chlorophenyl)-2-fluoroethylidene)isopropylamine

Downstream raw materials:

C₁₂H₁₄ClF

para-chloroacetophenone

1-(4-chlorophenyl)-2-fluoroethan-1-ol

1-(4-chlorophenyl)-2-fluoroethan-1-ol

Refernces

• 1、 Fan, Jiajie,Lin, Xianfu,Peng, Yongzhen,Wang, Anlin,Wu, Qi,Xu, Jian,Xu, Weihua,Yu, Huilei. "Double Enzyme-Catalyzed One-Pot Synthesis of Enantiocomplementary Vicinal Fluoro Alcohols". . . Retrieved 2020/07/24.
• 2、 Zhang, Rui,Ni, Chuanfa,He, Zhengbiao,Hu, Jinbo. "Decarboxylative fluorination of β-Ketoacids with N-fluorobenzenesulfonimide (NFSI) for the synthesis of α-fluoroketones: Substrate scope and mechanistic investigation". . p. 166 - 172. Retrieved 2017/09/18.