NSC56143

Base Information

• Chemical Name: NSC56143
• CAS No.: 2344-17-4
• Molecular Formula: C5H2Cl2F3N3
• Molecular Weight: 231.99
• Hs Code.: 2933599090
• Mol file: 2344-17-4.mol

Synonyms:Pyrimidine,5-amino-4,6-dichloro-2-(trifluoromethyl)- (7CI,8CI);NSC 56143;

Chemical Property of NSC56143

Chemical Property:

• Vapor Pressure: 0.306mmHg at 25°C
• Refractive Index: 1.523
• Boiling Point: 201.6 °C at 760 mmHg
• PKA: -5.17±0.10(Predicted)
• Flash Point: 75.7 °C
• PSA: 51.80000
• Density: 1.711 g/cm³
• LogP: 2.96560

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,6-Dichloro-2-(trifluoromethyl)pyrimidin-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NSC56143

There total 4 articles about NSC56143 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,6-dichloro-5-nitro-2-trifluoro-methyl-pyrimidine (715-46-8) → 4,6-dichloro-2-trifluoromethyl-pyrimidin-5-ylamine (2344-17-4)

Guidance literature:

With iron; acetic acid; at 50 ℃; for 1.25h;

Reference yield:

2-trifluoromethyl-4,6-dihydroxypyrimidine (672-47-9) → 4,6-dichloro-2-trifluoromethyl-pyrimidin-5-ylamine (2344-17-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / 15 h / 20 °C

1.2: 25 °C

2.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate; phosphoric acid / 20 - 45 °C / Inert atmosphere

3.1: acetic acid; iron / 1.25 h / 50 °C

With phosphoric acid; iron; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate;

Reference yield:

5-nitro-2-trifluoromethyl-1H-pyrimidine-4,6-dione (652-62-0) → 4,6-dichloro-2-trifluoromethyl-pyrimidin-5-ylamine (2344-17-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; trichlorophosphate; phosphoric acid / 20 - 45 °C / Inert atmosphere

2: acetic acid; iron / 1.25 h / 50 °C

With phosphoric acid; iron; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate;

upstream raw materials:

2-trifluoromethyl-4,6-dihydroxypyrimidine

4,6-dichloro-5-nitro-2-trifluoro-methyl-pyrimidine

5-nitro-2-trifluoromethyl-1H-pyrimidine-4,6-dione

Downstream raw materials:

N₄-{[(2S)-4-Benzylmorpholin-2-yl]methyl}-6-chloro-2-(trifluoromethyl)pyrimidine-4,5-diamine

3-{[(2R)-4-benzylmorpholin-2-yl]methyl}-7-chloro-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

3-{[(2R)-4-benzylmorpholin-2-yl]methyl}-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine

PF-04957325

Refernces

• 1、 -. "SUBSTITUTED TRIAZOLOPYRIMIDINES AS PDE8 INHIBITORS". . . Retrieved 2011/06/16.