Cyano-2-(p-methoxyphenyl)-4-methyl-pent-1-ene

Base Information

• Chemical Name: Cyano-2-(p-methoxyphenyl)-4-methyl-pent-1-ene
• CAS No.: 82938-21-4
• Molecular Formula: C₁₄H₁₇NO
• Molecular Weight: 215.295
• Mol file: 82938-21-4.mol

Synonyms:

Chemical Property of Cyano-2-(p-methoxyphenyl)-4-methyl-pent-1-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyano-2-(p-methoxyphenyl)-4-methyl-pent-1-ene

There total 1 articles about Cyano-2-(p-methoxyphenyl)-4-methyl-pent-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl 1-cyanomethylphosphonate (2537-48-6) + 3-methyl-1-(4-methoxyphenyl)-1-butanone (82938-20-3) → Cyano-2-(p-methoxyphenyl)-4-methyl-pent-1-ene (82938-21-4,82938-22-5)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1) THF, <5 degC, 2) 60 degC, 6h;

Reference yield: 80.0%

Cyano-2-(p-methoxyphenyl)-4-methyl-pent-1-ene (82938-21-4,82938-22-5) → 1-amino-3-(p-methoxyphenyl)-5-methyl-hex-2-ene (82938-23-6,82938-24-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 3h;

Reference yield:

Cyano-2-(p-methoxyphenyl)-4-methyl-pent-1-ene (82938-21-4,82938-22-5) → 13-Aza-3-methoxy-7-methyl-18-nor-5,6-seco-estrone (82938-29-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / LAH / diethyl ether / 3 h / 0 °C

2: 34 percent / 4 h / 190 - 200 °C

3: 54 percent / NaBH₄ / aq. ethanol / 0 °C / 1) addition of 2N HCl in 10min intervalls over 5h 2) pH 3, 1h

4: 35 percent / PTS / benzene / 0.75 h / Heating

5: 38 percent / H₂ / PtO₂, acetic acid / ethanol

With sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; pyridinium p-toluenesulfonate; platinum(IV) oxide; acetic acid; In diethyl ether; ethanol; benzene;

upstream raw materials:

diethyl 1-cyanomethylphosphonate

3-methyl-1-(4-methoxyphenyl)-1-butanone

Downstream raw materials:

1-amino-3-(p-methoxyphenyl)-5-methyl-hex-2-ene

13-Aza-3-methoxy-7-methyl-18-nor-5,6-seco-estrone

13-Aza-3-methoxy-7-methyl-18-nor-5,6-seco-Δ^9,11-estrone

N-<3-(p-Methoxyphenyl)-5-methylhex-2-enyl>succinimide

Refernces