Technology Process of 9-methyl-5-[(4-methylphenyl)sulfonyl]-2,3,5,9-tetrahydro-6H-pyrazolo[4,3-h]pyrrolo[4,3,2-de]quinolin-6-one
There total 12 articles about 9-methyl-5-[(4-methylphenyl)sulfonyl]-2,3,5,9-tetrahydro-6H-pyrazolo[4,3-h]pyrrolo[4,3,2-de]quinolin-6-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: POCl3 / 1.5 h / 0 °C
2.1: ammonium acetate; acetic acid / 3 h / Heating
3.1: KOH / tetrahydrofuran / 0.08 h / 0 °C
3.2: 54 percent / tetrahydrofuran / 1 h / 20 °C
4.1: LiAlH4 / diethyl ether; CH2Cl2 / 0.25 h / 0 °C
5.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C
5.2: 200 mg / tetrahydrofuran / 1 h / 20 °C
6.1: CAN / acetonitrile; H2O / 0.25 h / 20 °C
With
ammonium acetate; potassium hydroxide; lithium aluminium tetrahydride; ammonium cerium(IV) nitrate; sodium hydride; acetic acid; trichlorophosphate;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1021/jm051247f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: KOH / tetrahydrofuran / 0.08 h / 0 °C
1.2: 54 percent / tetrahydrofuran / 1 h / 20 °C
2.1: LiAlH4 / diethyl ether; CH2Cl2 / 0.25 h / 0 °C
3.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C
3.2: 200 mg / tetrahydrofuran / 1 h / 20 °C
4.1: CAN / acetonitrile; H2O / 0.25 h / 20 °C
With
potassium hydroxide; lithium aluminium tetrahydride; ammonium cerium(IV) nitrate; sodium hydride;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1021/jm051247f
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C
1.2: 1.53 g / tetrahydrofuran / 0.5 h / 20 °C
2.1: CAN / acetonitrile; H2O / 0.25 h / 20 °C
With
ammonium cerium(IV) nitrate; sodium hydride;
In
tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jm051247f