N-(N-benzyloxycarbonyl-L-leucyl)-L-valine amide

Base Information

• Chemical Name: N-(N-benzyloxycarbonyl-L-leucyl)-L-valine amide
• CAS No.: 14611-15-5
• Molecular Formula: C₁₉H₂₉N₃O₄
• Molecular Weight: 363.457
• Mol file: 14611-15-5.mol

Synonyms:

Chemical Property of N-(N-benzyloxycarbonyl-L-leucyl)-L-valine amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N-benzyloxycarbonyl-L-leucyl)-L-valine amide

There total 3 articles about N-(N-benzyloxycarbonyl-L-leucyl)-L-valine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Z-Leu-OH (2018-66-8) + (S)-2-amino-3-methylbutanamide hydrochloride (3014-80-0) → N-(N-benzyloxycarbonyl-L-leucyl)-L-valine amide (14611-15-5)

Guidance literature:

With borate buffer; pronase EC 3.4.24.4; triethylamine; In acetonitrile; for 25h; Ambient temperature;

Reference yield:

Z-Leu-OPCP (13758-71-9) + (S)-2-amino-3-methylbutanamide hydrobromide (33529-85-0) → N-(N-benzyloxycarbonyl-L-leucyl)-L-valine amide (14611-15-5)

Guidance literature:

With N-ethylmorpholine;; benzotriazol-1-ol; In N,N-dimethyl-formamide;

Reference yield:

→ N-(N-benzyloxycarbonyl-L-leucyl)-L-valine amide (14611-15-5)

Guidance literature:

DOI:10.1002/hlca.19730560533

upstream raw materials:

Z-Leu-OPCP

(S)-2-amino-3-methylbutanamide hydrobromide

Z-Leu-OH

(S)-2-amino-3-methylbutanamide hydrochloride

Refernces