1,2-Dimethoxy-4,5-dimethylbenzene

Base Information

• Chemical Name: 1,2-Dimethoxy-4,5-dimethylbenzene
• CAS No.: 1128-57-0
• Molecular Formula: C10H14O2
• Molecular Weight: 166.22
• DSSTox Substance ID: DTXSID20596339
• Nikkaji Number: J1.043.439D
• Wikidata: Q82491568
• Mol file: 1128-57-0.mol

Synonyms:1128-57-0;1,2-Dimethoxy-4,5-dimethylbenzene;4,5-dimethylveratrol;4,5-dimethylveratrole;SCHEMBL1912056;DTXSID20596339;VCFFLBDRLPCAPF-UHFFFAOYSA-N;1,2-Dimethyl-4,5-dimethoxybenzol

Chemical Property of 1,2-Dimethoxy-4,5-dimethylbenzene

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 166.099379685
• Heavy Atom Count: 12
• Complexity: 120

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1C)OC)OC

Technology Process of 1,2-Dimethoxy-4,5-dimethylbenzene

There total 12 articles about 1,2-Dimethoxy-4,5-dimethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-bromo-4,5-dimethoxy-2-methylbenzene (52806-46-9) + methyl iodide (74-88-4) → 1,2-dimethoxy-4,5-dimethylbenzene (1128-57-0)

Guidance literature:

1-bromo-4,5-dimethoxy-2-methylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol200808q

Reference yield: 90.0%

1,2-bis(bromomethyl)-4,5-dimethoxybenzene (26726-81-8) → 1,2-dimethoxy-4,5-dimethylbenzene (1128-57-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

DOI:10.1021/ol900371m

Reference yield: 78.2%

methanol (67-56-1) + 2-methoxy-4,4-dimethylcyclohexa-2,5-dien-1-one (42117-30-6) → 1,2-dimethoxy-4,5-dimethylbenzene (1128-57-0)

Guidance literature:

With boron trifluoride diethyl etherate; for 1h; Heating;

upstream raw materials:

4,5-dimethoxy-2-methylbenzaldehyde

4,5-Dichlor-brenzcatechindimethylether

methyllithium

methanol

Downstream raw materials:

3,6-Bis-chloromethyl-4,5-dimethyl-benzene-1,2-diol

Refernces

• 1、 Chebny, Vincent J.,Shukla, Ruchi,Lindeman, Sergey V.,Rathore, Rajendra. "Molecular actuator: Redox-controlled clam-like motion in a bichromophoric electron donor". supporting information; experimental part. p. 1939 - 1942. Retrieved 2009/09/25.
• 2、 Li, Chaozhong,Angelici, Robert J.. "A facile synthesis of functionalized catechols". . p. 4235 - 4238. Retrieved 2007/10/03.