N-(2',3'-dimethoxyphenyl)-4-bromo-2,5-dimethylacetanilide

Base Information

• Chemical Name: N-(2',3'-dimethoxyphenyl)-4-bromo-2,5-dimethylacetanilide
• CAS No.: 198994-79-5
• Molecular Formula: C₁₈H₂₀BrNO₃
• Molecular Weight: 378.266
• Mol file: 198994-79-5.mol

Synonyms:

Chemical Property of N-(2',3'-dimethoxyphenyl)-4-bromo-2,5-dimethylacetanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2',3'-dimethoxyphenyl)-4-bromo-2,5-dimethylacetanilide

There total 1 articles about N-(2',3'-dimethoxyphenyl)-4-bromo-2,5-dimethylacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

2,5-dibromo-p-xylene (1074-24-4) + N-(2,3-dimethoxyphenyl)acetamide (121639-09-6) → N-(2',3'-dimethoxyphenyl)-4-bromo-2,5-dimethylacetanilide (198994-79-5)

Guidance literature:

With copper(I) oxide; potassium carbonate; at 180 ℃; for 37.5h;

Reference yield: 73.0%

N-(2',3'-dimethoxyphenyl)-4-bromo-2,5-dimethylacetanilide (198994-79-5) → N-(2',3'-dimethoxyphenyl)-4-bromo-2,5-dimethylaniline (198994-80-8)

Guidance literature:

With potassium hydroxide; In ethanol; for 15.5h; Heating;

Reference yield:

N-(2',3'-dimethoxyphenyl)-4-bromo-2,5-dimethylacetanilide (198994-79-5) → N-(2',3'-dimethoxyphenyl)-4-acetoxy-2,5-dimethylaniline

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / aq.KOH / ethanol / 15.5 h / Heating

2: 7 percent / palladium(II) acetate, AcOH / 1.5 h / Heating

With potassium hydroxide; palladium diacetate; acetic acid; In ethanol;

upstream raw materials:

2,5-dibromo-p-xylene

N-(2,3-dimethoxyphenyl)acetamide

Downstream raw materials:

N-(2',3'-dimethoxyphenyl)-4-bromo-2,5-dimethylaniline

Refernces