Hexanoic acid, 2-hydroxy-, ethyl ester, (R)-

Base Information

• Chemical Name: Hexanoic acid, 2-hydroxy-, ethyl ester, (R)-
• CAS No.: 113747-69-6
• Molecular Formula: C8H16O3
• Mol file: 113747-69-6.mol

Synonyms:

Chemical Property of Hexanoic acid, 2-hydroxy-, ethyl ester, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hexanoic acid, 2-hydroxy-, ethyl ester, (R)-

There total 3 articles about Hexanoic acid, 2-hydroxy-, ethyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-hydroxyhexanoic acid ethyl ester (52089-55-1) → ethyl (R)-α-hydroxyhexanoate (113747-69-6) + (R)-2-hydroxyhexanoic acid (43201-07-6) + (S)-2-hydroxyhexanoic acid (70267-26-4)

Guidance literature:

With water; Pseudomonas lipase enzyme; Yield given. Title compound not separated from byproducts; Ambient temperature; 0.05 M aq. phosphate buffer (pH 7.0);

DOI:10.1021/jo00290a007

Reference yield: 24.0%

2-hydroxyhexanoic acid ethyl ester (52089-55-1) → ethyl (R)-α-hydroxyhexanoate (113747-69-6) + (S)-2-hydroxyhexanoic acid ethyl ester (93097-40-6) + (R)-2-hydroxyhexanoic acid (43201-07-6) + (S)-2-hydroxyhexanoic acid (70267-26-4)

Guidance literature:

With water; Pseudomonas lipase enzyme; Yield given. Title compound not separated from byproducts; Ambient temperature; 0.05 M aq. phosphate buffer (pH 7.0);

DOI:10.1021/jo00290a007

Reference yield:

ethanol (64-17-5) + 5-butyl-[1,3]dioxolane-2,4-dione → ethyl (R)-α-hydroxyhexanoate (113747-69-6) + (S)-2-hydroxyhexanoic acid ethyl ester (93097-40-6) + (R)-2-hydroxyhexanoic acid (43201-07-6) + (S)-2-hydroxyhexanoic acid (70267-26-4)

Guidance literature:

ethanol; 5-butyl-[1,3]dioxolane-2,4-dione; With hydroquinidine anthraquinone-1,4-diyl diether; In diethyl ether; at -78 ℃; for 36h;

With water; Further stages. Title compound not separated from byproducts.;

DOI:10.1021/ja0255047

upstream raw materials:

2-hydroxyhexanoic acid ethyl ester

ethanol

Refernces

• 1、 Kalaritis,Regenye,Patridge,Coffen. "Kinetic resolution of 2-substituted esters catalyzed by a lipase ex. Pseudomonas fluorescens". . p. 812 - 815. Retrieved 2007/10/02.