N-(2-chloro-4-nitrophenyl)acetamide

Base Information

• Chemical Name: N-(2-chloro-4-nitrophenyl)acetamide
• CAS No.: 881-87-8
• Molecular Formula: C8H7 Cl N2 O3
• Molecular Weight: 214.608
• NSC Number: 23792,8276
• DSSTox Substance ID: DTXSID30278578
• Nikkaji Number: J1.235.987J
• Wikidata: Q82010562
• Mol file: 881-87-8.mol

Synonyms:N-(2-chloro-4-nitrophenyl)acetamide;881-87-8;NSC 8276;Acetanilide, 2'-chloro-4'-nitro-;NSC 23792;Acetamide, N-(2-chloro-4-nitrophenyl)-;NSC8276;SCHEMBL8930598;DTXSID30278578;NSC-8276;NSC23792;MFCD00466843;NSC-23792;STL289211;AKOS000436823;CCG-233434;CS-0322143;FT-0711503;AE-641/00419063

Chemical Property of N-(2-chloro-4-nitrophenyl)acetamide

Chemical Property:

• Vapor Pressure: 7.04E-07mmHg at 25°C
• Boiling Point: 408.4°C at 760 mmHg
• Flash Point: 200.8°C
• Density: 1.466g/cm³
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 214.0145198
• Heavy Atom Count: 14
• Complexity: 241

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])Cl

Technology Process of N-(2-chloro-4-nitrophenyl)acetamide

There total 14 articles about N-(2-chloro-4-nitrophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(2-chlorophenyl)acetamide (533-17-5) → N-(2-chloro-4-nitrophenyl)acetamide (881-87-8)

Guidance literature:

With ammonium molybdate; water; nitric acid; In chloroform; for 6h; Heating;

DOI:10.1246/cl.2000.48

Reference yield: 99.0%

N-(4-Nitrophenyl)acetamide (104-04-1) → N-(2-chloro-4-nitrophenyl)acetamide (881-87-8)

Guidance literature:

With N-chloro-N-(benzenesulfonyl)benzenesulfonamide; In acetonitrile; at 20 - 25 ℃; for 0.166667h; Green chemistry;

DOI:10.1016/j.tetlet.2020.152689

Reference yield: 95.0%

trimethylsilyl acetate (2754-27-0) + 2-Chloro-4-nitroaniline (121-87-9) → N-(2-chloro-4-nitrophenyl)acetamide (881-87-8)

Guidance literature:

With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride; In dichloromethane; for 20h; Ambient temperature;

DOI:10.1246/cl.1993.1053

upstream raw materials:

N-(2-chlorophenyl)acetamide

N-(4-Nitrophenyl)acetamide

N-chloro-p-nitroacetanilide

acetic anhydride

Downstream raw materials:

2-Chloro-4-nitroaniline

N-(4-Amino-2-chloro-phenyl)-acetamide

C₁₃H₁₅ClN₄O₅

1,2-bis(2-chloro-4-nitrophenyl)disulfane

Refernces

• 1、 Dai, Enrui,Dong, Ying,Dong, Yongrui,Kong, Rui,Liang, Deqiang,Liu, Guangzhang,Ma, Yinhai,Wu, Qiong. "Transition-metal-free mono- or dinitration of protected anilines". . . Retrieved 2020/04/27.
• 2、 -. "ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS". Paragraph 0112. . Retrieved 2013/05/21.