ethyl 5-chloro-3-(o-chlorophenyl)-indole-2-carboxylate

Base Information

• Chemical Name: ethyl 5-chloro-3-(o-chlorophenyl)-indole-2-carboxylate
• CAS No.: 24107-07-1
• Molecular Formula: C₁₇H₁₃Cl₂NO₂
• Molecular Weight: 334.202
• Mol file: 24107-07-1.mol

Synonyms:

Chemical Property of ethyl 5-chloro-3-(o-chlorophenyl)-indole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-chloro-3-(o-chlorophenyl)-indole-2-carboxylate

There total 1 articles about ethyl 5-chloro-3-(o-chlorophenyl)-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ ethyl 5-chloro-3-(o-chlorophenyl)-indole-2-carboxylate (24107-07-1)

Guidance literature:

Hydrazon IIIb, HCl;

Reference yield:

ethyl 5-chloro-3-(o-chlorophenyl)-indole-2-carboxylate (24107-07-1) → 4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-<(benzyloxycarbonyl)glycyl>glycinanilide (59179-98-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, RT, 1.5 h, 2.) DMF, RT, overnight

2: 98.5 percent / 86percent KOH / ethanol / 2 h / Heating

3: 1.) SOCl₂, 2.) NH₃ (gas) / 1.) reflux, 3 h, 2.) THF, RT, 3 h

4: LiAlH₄ / diethyl ether / a) RT, 10.5 h, b) reflux, 4 h

5: 1.) SOCl₂, HMPA, 2.) Et₃N / 1.) -5 deg C, 10 min, 2.) Et₂O, RT, overnight

6: 37.2 percent / CrO₃ / acetic acid; H₂O / Ambient temperature

With chromium(VI) oxide; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ammonia; sodium hydride; triethylamine; In diethyl ether; ethanol; water; acetic acid;

DOI:10.1021/jm00181a013

Reference yield:

ethyl 5-chloro-3-(o-chlorophenyl)-indole-2-carboxylate (24107-07-1) → 5-chloro-3-(o-chlorophenyl)-1-methylindole-2-carboxylic acid (74098-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, RT, 1.5 h, 2.) DMF, RT, overnight

2: 98.5 percent / 86percent KOH / ethanol / 2 h / Heating

With potassium hydroxide; sodium hydride; In ethanol;

DOI:10.1021/jm00181a013

Downstream raw materials:

ethyl 5-chloro-3-(o-chlorophenyl)-1-methylindole-2-carboxylate

2-Amino-N-({[4-chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-3-phenyl-propionamide

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-glycylglycinanilide

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide