Technology Process of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-(p-nitrophenyl)cytosine
There total 11 articles about 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-(p-nitrophenyl)cytosine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonium hydroxide;
In
1,4-dioxane;
for 8h;
Yield given;
Ambient temperature;
DOI:10.1080/15257779408013228
- Guidance literature:
-
Multi-step reaction with 7 steps
1: (NH4)2SO4 / 2 h / Heating
2: 40 percent / CH2Cl2 / 120 h / Ambient temperature
3: NH3, MeOH / 48 h / Ambient temperature
4: pyridine
5: 41 percent / EtONO2, conc. H2SO4 / CH2Cl2; nitromethane / 1.5 h / -10 °C
6: 1,2,4-triazole, POCl3 / acetonitrile / 1.5 h / Ambient temperature
7: NH4OH / dioxane / 8 h / Ambient temperature
With
pyridine; 1,2,4-Triazole; methanol; ammonium sulfate; ammonium hydroxide; ethyl nitrate; sulfuric acid; ammonia; trichlorophosphate;
In
1,4-dioxane; nitromethane; dichloromethane; acetonitrile;
DOI:10.1080/15257779408013228
- Guidance literature:
-
Multi-step reaction with 8 steps
2: (NH4)2SO4 / 2 h / Heating
3: 40 percent / CH2Cl2 / 120 h / Ambient temperature
4: NH3, MeOH / 48 h / Ambient temperature
5: pyridine
6: 41 percent / EtONO2, conc. H2SO4 / CH2Cl2; nitromethane / 1.5 h / -10 °C
7: 1,2,4-triazole, POCl3 / acetonitrile / 1.5 h / Ambient temperature
8: NH4OH / dioxane / 8 h / Ambient temperature
With
pyridine; 1,2,4-Triazole; methanol; ammonium sulfate; ammonium hydroxide; ethyl nitrate; sulfuric acid; ammonia; trichlorophosphate;
In
1,4-dioxane; nitromethane; dichloromethane; acetonitrile;
DOI:10.1080/15257779408013228