TERT-BUTYL 2-IODOETHYLCARBAMATE

Base Information

• Chemical Name: TERT-BUTYL 2-IODOETHYLCARBAMATE
• CAS No.: 122234-46-2
• Molecular Formula: C7H14INO2
• Molecular Weight: 271.098
• Mol file: 122234-46-2.mol

Synonyms:tert-butyl N-(2-iodoethyl)carbamate;

Chemical Property of TERT-BUTYL 2-IODOETHYLCARBAMATE

Chemical Property:

• Boiling Point: 281.3±23.0 °C(Predicted)
• PKA: 11.93±0.46(Predicted)
• PSA: 38.33000
• Density: 1.546±0.06 g/cm3(Predicted)
• LogP: 2.33700
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl(2-Iodoethyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl (2-Iodoethyl)carbamate can be used as antiviral agents.

Technology Process of TERT-BUTYL 2-IODOETHYLCARBAMATE

There total 7 articles about TERT-BUTYL 2-IODOETHYLCARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1H-imidazole (288-32-4) + 2-(N-tert-butoxycarbonylamino)ethanol (26690-80-2) → 2-iodo-1-<(tert-butyloxycarbonyl)amino>ethane (122234-46-2)

Guidance literature:

With iodine; triphenylphosphine; In dichloromethane;

Reference yield: 70.2%

2-(tert-butoxycarbonylamino)ethyl bromide (39684-80-5) → 2-iodo-1-<(tert-butyloxycarbonyl)amino>ethane (122234-46-2)

Guidance literature:

With sodium iodide; In acetone; for 24h; Ambient temperature;

DOI:10.1021/jm00108a004

Reference yield: 64.0%

2-(N-tert-butoxycarbonylamino)ethanol (26690-80-2) → 2-iodo-1-<(tert-butyloxycarbonyl)amino>ethane (122234-46-2)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo901219k

upstream raw materials:

2-(tert-butoxycarbonylamino)ethyl bromide

2-(N-tert-butoxycarbonylamino)ethanol

di-tert-butyl dicarbonate

iodine

Downstream raw materials:

?tert-butyl [2-(chlorosulfonyl)ethyl]carbamate

2-[(tert-butoxycarbonyl)amino]-1-ethanethiol

Refernces

• 1、 Crich, David,Rahaman, Md. Yeajur. "Thiomaleic anhydride: A convenient building block for the synthesis of α-substituted γ- and δ-lactones through free-radical addition, nucleophilic ring opening, and subsequent thiocarboxylate manipulation". supporting information; experimental part. p. 6792 - 6796. Retrieved 2009/12/31.
• 2、 -. "ALKYLOXY SUBSTITUTED THIAZOLOQUINOLINES AND THIAZOLONAPHTHYRIDINES". Page/Page column 101. . Retrieved 2008/06/13.