Carbamic acid, [4-(phenylmethoxy)-2-naphthalenyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [4-(phenylmethoxy)-2-naphthalenyl]-, 1,1-dimethylethyl ester
• CAS No.: 122745-36-2
• Molecular Formula: C22H23NO3
• Molecular Weight: 349.43
• Mol file: 122745-36-2.mol

Synonyms:

Chemical Property of Carbamic acid, [4-(phenylmethoxy)-2-naphthalenyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [4-(phenylmethoxy)-2-naphthalenyl]-, 1,1-dimethylethyl ester

There total 13 articles about Carbamic acid, [4-(phenylmethoxy)-2-naphthalenyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-Amino-1-(benzyloxy)naphthalene (122745-35-1) → N-(tert-butyloxycarbonyl)-4-(benzyloxy)-2-naphthylamine (122745-36-2)

Guidance literature:

In 1,4-dioxane; at 95 ℃; for 3h;

DOI:10.1021/jo00310a013 DOI:10.1021/ja00198a089

Reference yield: 83.0%

benzyl bromide (100-39-0) + tert-butyl-(4-hydroxynaphthalen-2-yl)carbamate (139975-98-7) → N-(tert-butyloxycarbonyl)-4-(benzyloxy)-2-naphthylamine (122745-36-2)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 23 ℃; for 8h;

DOI:10.1021/jo00036a023

Reference yield:

2,4-dinitronaphthalene (606-37-1) → N-(tert-butyloxycarbonyl)-4-(benzyloxy)-2-naphthylamine (122745-36-2)

Guidance literature:

Multi-step reaction with 2 steps

2: 96 percent / dioxane / 3 h / 95 °C

In 1,4-dioxane;

DOI:10.1021/ja00198a089

upstream raw materials:

di-tert-butyl dicarbonate

3-Amino-1-(benzyloxy)naphthalene

benzyl bromide

tert-butyl-(4-hydroxynaphthalen-2-yl)carbamate

Downstream raw materials:

tert-butyl (S)-1-(chloromethyl)-5-((4-methylpiperazine-1-carbonyl)oxy)-1,2-dihydro-3H-benzo[e]indole-3-carboxylate

(R)-tert-butyl (4-(benzyloxy)-1-iodonaphthalen-2-yl)(oxiran-2-ylmethyl)carbamate

Refernces

• 1、 -. "G-A CROSSLINKING CYTOTOXIC AGENTS". . . Retrieved 2020/08/22.
• 2、 -. "SELF-IMMOLATIVE LINKERS CONTAINING MANDELIC ACID DERIVATIVES, DRUG-LIGAND CONJUGATES FOR TARGETED THERAPIES AND USES THEREOF". Page/Page column 51; 86; 87; 91. . Retrieved 2015/03/28.