1-(2,3-dihydroxy-6-methoxy-phenyl)-ethanone

Base Information

• Chemical Name: 1-(2,3-dihydroxy-6-methoxy-phenyl)-ethanone
• CAS No.: 56358-73-7
• Molecular Formula: C₉H₁₀O₄
• Molecular Weight: 182.176
• Mol file: 56358-73-7.mol

Synonyms:

Chemical Property of 1-(2,3-dihydroxy-6-methoxy-phenyl)-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,3-dihydroxy-6-methoxy-phenyl)-ethanone

There total 8 articles about 1-(2,3-dihydroxy-6-methoxy-phenyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2'-hydroxy-6'-methoxyacetophenone (703-23-1) → 6-methoxy-2,5-dihydroxyacetophenone (33539-20-7) + 1-(2,3-dihydroxy-6-methoxy-phenyl)-ethanone (56358-73-7)

Guidance literature:

2'-hydroxy-6'-methoxyacetophenone; With sodium hydroxide; dipotassium peroxodisulfate; In water; at 20 ℃;

With hydrogenchloride; sodium sulfite; In water; for 2h; Heating / reflux;

Reference yield:

→ 1-(2,3-dihydroxy-6-methoxy-phenyl)-ethanone (56358-73-7)

Guidance literature:

With hydrogenchloride; acetic acid; at 60 ℃;

DOI:10.1039/jr9480002138

Reference yield:

2'-hydroxy-6'-methoxyacetophenone (703-23-1) → 1-(2,3-dihydroxy-6-methoxy-phenyl)-ethanone (56358-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃; diethyl ether; HCl / Erwaermen des Reaktionsprodukts mit Wasser

2: aq. NaOH solution; aqueous H₂O₂

With hydrogenchloride; sodium hydroxide; aluminium trichloride; diethyl ether; dihydrogen peroxide;

DOI:10.1039/jr9480002138

upstream raw materials:

2,6-dihydroxylacetophenone

3-acetyl-2-hydroxy-4-methoxy-benzaldehyde

2,6-Diacetyl-3-methoxy-phenol

2'-hydroxy-6'-methoxyacetophenone

Downstream raw materials:

5,6-diacetoxy-2-phenyl-chromen-4-one

8-hydroxy-5-methoxy-2-phenyl-chromen-4-one

5,6-Dihydroxyflavone

primetin

Refernces