Cyclohexen-1-yl 1-methylindol-2-yl ketone

Base Information

• Chemical Name: Cyclohexen-1-yl 1-methylindol-2-yl ketone
• CAS No.: 155592-24-8
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 239.317
• Mol file: 155592-24-8.mol

Synonyms:

Chemical Property of Cyclohexen-1-yl 1-methylindol-2-yl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexen-1-yl 1-methylindol-2-yl ketone

There total 2 articles about Cyclohexen-1-yl 1-methylindol-2-yl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methylindole (603-76-9) + 1-iodo-1-cyclohexene (17497-53-9) + carbon monoxide (201230-82-2) → 2-ethyl-1-methyl-1H-indole (65136-45-0) + Cyclohexen-1-yl 1-methylindol-2-yl ketone (155592-24-8)

Guidance literature:

With triethyl borane; tert.-butyl lithium; bis-triphenylphosphine-palladium(II) chloride; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, pentane, hexane, r.t., 1 h; -20 deg C, 1 h, 2.) THF, 15 atm., 60 deg C, 40 h;

DOI:10.1021/jo00088a060

Reference yield:

1-methylindole (603-76-9) + carbon monoxide (201230-82-2) + cyclohex-1-en-1-yl trifluoromethane sulfonate (28075-50-5) → Cyclohexen-1-yl 1-methylindol-2-yl ketone (155592-24-8)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; triethyl borane; tert.-butyl lithium; Yield given. Multistep reaction;

DOI:10.3987/COM-95-7095

upstream raw materials:

1-methylindole

1-iodo-1-cyclohexene

carbon monoxide

cyclohex-1-en-1-yl trifluoromethane sulfonate

Refernces

• 1、 Ishikura, Minoru. "A CONCISE APPROACH TO ANTIFERTILITY AGENTS; STRUCTURAL ANALOGUES OF YUEHCHUKENE". . p. 1385 - 1388. Retrieved 2007/10/02.