3,4-DIMETHYLHIPPURIC ACID

Base Information

• Chemical Name: 3,4-DIMETHYLHIPPURIC ACID
• CAS No.: 23082-12-4
• Molecular Formula: C11H13NO3
• Molecular Weight: 207.23
• Hs Code.: 2924299090
• Mol file: 23082-12-4.mol

Synonyms:N-(3, 4-Dimethylbenzoyl)glycine;

Chemical Property of 3,4-DIMETHYLHIPPURIC ACID

Chemical Property:

• Melting Point: 160 °C
• Boiling Point: 406.2 °C at 760 mmHg
• PKA: 3.72±0.10(Predicted)
• Flash Point: 199.4 °C
• PSA: 66.40000
• Density: 1.194 g/cm³
• LogP: 1.50870
• Solubility.: almost transparency in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-[(3,4-Dimethylphenyl)formamido]aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-DIMETHYLHIPPURIC ACID

There total 3 articles about 3,4-DIMETHYLHIPPURIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-(3,4-dimethylbenzamido)acetate → 2-(3,4-dimethylbenzamido)acetic acid (23082-12-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 15 ℃; for 20h;

Reference yield:

3,4-dimethylbenzoic acid (619-04-5) → 2-(3,4-dimethylbenzamido)acetic acid (23082-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 15 °C

2: trifluoroacetic acid / dichloromethane / 20 h / 15 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

→ 2-(3,4-dimethylbenzamido)acetic acid (23082-12-4)

Guidance literature:

entspr.Benzoesaeure 1) SOCl2 2) Glycin;

DOI:10.1007/BF01216470

upstream raw materials:

3,4-dimethylbenzoic acid

Refernces

• 1、 -. "COMPOUNDS AND USES THEREOF". . . Retrieved 2018/05/17.