trifluoromethyl 4-fluorobenzene-1-sulfonate

Base Information

• Chemical Name: trifluoromethyl 4-fluorobenzene-1-sulfonate
• CAS No.: 2070902-77-9
• Molecular Formula: C₇H₄F₄O₃S
• Molecular Weight: 244.167
• Mol file: 2070902-77-9.mol

Synonyms:

Chemical Property of trifluoromethyl 4-fluorobenzene-1-sulfonate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trifluoromethyl 4-fluorobenzene-1-sulfonate

There total 2 articles about trifluoromethyl 4-fluorobenzene-1-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

Togni's reagent (887144-97-0) + 4-fluorobenzenesulfonic acid (368-88-7) → trifluoromethyl 4-fluorobenzene-1-sulfonate (2070902-77-9)

Guidance literature:

In chloroform; tert-butyl alcohol; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

4-Fluorobenzenesulfonyl chloride (349-88-2) → trifluoromethyl 4-fluorobenzene-1-sulfonate (2070902-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: water / 1,4-dioxane / 6 h / Reflux

2: chloroform; tert-butyl alcohol / 12 h / 20 °C / Inert atmosphere

With water; In 1,4-dioxane; chloroform; tert-butyl alcohol;

Reference yield: 88.0%

trifluoromethyl 4-fluorobenzene-1-sulfonate (2070902-77-9) + C22H24O10 → C23H23Br2F3O11

Guidance literature:

C₂₂H₂₄O₁₀; With potassium fluoride; N-bromophthalimide; 18-crown-6 ether; silver carbonate; In acetonitrile; at 20 ℃; for 0.0833333h; Sealed tube;

trifluoromethyl 4-fluorobenzene-1-sulfonate; In acetonitrile; at 60 ℃; for 4h;

upstream raw materials:

4-Fluorobenzenesulfonyl chloride

Togni's reagent

4-fluorobenzenesulfonic acid

Downstream raw materials:

4-fluorobenzenesulfonyl fluoride

Refernces

• 1、 -. "Bromotrifluoromethoxy compound and synthetic method thereof". . . Retrieved 2017/08/27.