C₃₀H₂₅N₃O₄S₂

Base Information

• Chemical Name: C₃₀H₂₅N₃O₄S₂
• CAS No.: 1271450-08-8
• Molecular Formula: C₃₀H₂₅N₃O₄S₂
• Molecular Weight: 555.678
• Mol file: 1271450-08-8.mol

Synonyms:

Chemical Property of C₃₀H₂₅N₃O₄S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₂₅N₃O₄S₂

There total 5 articles about C₃₀H₂₅N₃O₄S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-1-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)but-3-en-2-one + (S)-11-thioxo-2,3,11,11a-tetrahydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(10H)-one (188115-27-7) → C30H25N3O4S2 (1271450-08-8)

Guidance literature:

(S)-11-thioxo-2,3,11,11a-tetrahydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(10H)-one; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.5h; Inert atmosphere;

(E)-1-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)but-3-en-2-one; In dimethyl sulfoxide; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo101864n

Reference yield:

(S)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione (24919-40-2,60269-66-1,18877-34-4) → C30H25N3O4S2 (1271450-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: P₂S₅-pyridine / acetonitrile / 3 h / 60 °C

2.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With P₂S₅-pyridine; sodium hydride; In dimethyl sulfoxide; acetonitrile;

DOI:10.1021/jo101864n

Reference yield:

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) → C30H25N3O4S2 (1271450-08-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 10 h / 20 °C

2.1: methanol / 72 h / Reflux

3.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; sodium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide; 2.1: Wittig reaction;

DOI:10.1021/jo101864n

upstream raw materials:

(S)-11-thioxo-2,3,11,11a-tetrahydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(10H)-one

Indole-3-carboxaldehyde

isatoic anhydride

(S)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione

Downstream raw materials:

C₃₀H₂₅N₃O₄S

Refernces