cis-10-decarbamoyl-1,10-dihydroxy-2,7-diaminomitosene

Base Information

• Chemical Name: cis-10-decarbamoyl-1,10-dihydroxy-2,7-diaminomitosene
• CAS No.: 92761-60-9
• Molecular Formula: C₁₃H₁₅N₃O₄
• Molecular Weight: 277.28
• Mol file: 92761-60-9.mol

Synonyms:

Chemical Property of cis-10-decarbamoyl-1,10-dihydroxy-2,7-diaminomitosene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-10-decarbamoyl-1,10-dihydroxy-2,7-diaminomitosene

There total 4 articles about cis-10-decarbamoyl-1,10-dihydroxy-2,7-diaminomitosene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.8%

mitomycin C (50-07-7) → trans-1-hydroxy-2,7-diaminomitosene (99745-88-7,78655-54-6) + 2β,7-Diamino-1β-hydroxymitosene (98462-75-0,78655-54-6) + 10-decarbamoyl-2,7-diaminomitosene (102587-27-9) + 2,7-Diaminomitosene (92695-32-4) + trans-10-decarbamoyl-1,10-dihydroxy-2,7-diaminomitosene (92761-61-0) + cis-10-decarbamoyl-1,10-dihydroxy-2,7-diaminomitosene (92761-60-9)

Guidance literature:

With chromium(II) perchlorate; 2-[Bis(2-hydroxyethyl)imino]-2-(hydroxymethyl)-1,3-propanediol Hydrochloride; In water; for 0.5h; Product distribution; Mechanism; Ambient temperature; other solvents, var. pH; other reaction partners;

Reference yield:

mitomycin C (50-07-7) → 10-decarbamoyl-2,7-diaminomitosene (102587-27-9) + 10-decarbamoyl-1-hydroxy-2,7-diaminomitosene (70013-26-2,86701-39-5,86701-40-8,92761-60-9,92761-61-0) + 2,7-Diaminomitosene (92695-32-4) + 2,7-diamino-1-hydroxymitosene (1192552-64-9,78655-54-6)

Guidance literature:

With chromium(II) perchlorate; water; for 0.5h; Product distribution; Mechanism; Ambient temperature; also activated mitomycin; pvar. pH values;

DOI:10.1021/ja00167a097

Reference yield:

mitomycin C (50-07-7) → 10-decarbamoyl-2,7-diaminomitosene (102587-27-9) + 2,7-Diaminomitosene (92695-32-4) + cis-10-decarbamoyl-1,10-dihydroxy-2,7-diaminomitosene (92761-60-9) + 10-decarbamoyl mitomycin C (26909-37-5)

Guidance literature:

With water; tetraethylammonium perchlorate; In N,N-dimethyl-formamide; Further byproducts given; electrochemical reduction at -0.950 V vs. Ag/AgCl, 3 M NaCl;

DOI:10.1021/ja00274a052

upstream raw materials:

mitomycin C

Refernces

• 1、 Kohn,Hong. "Observations on the activation of mitomycin C. Requirements for C-10 functionalization". . p. 4596 - 4598. Retrieved 2007/10/02.