Technology Process of Toluene-4-sulfonic acid (S)-1-((2R,3S)-2-methoxy-tetrahydro-furan-3-ylmethyl)-2-methyl-propyl ester
There total 5 articles about Toluene-4-sulfonic acid (S)-1-((2R,3S)-2-methoxy-tetrahydro-furan-3-ylmethyl)-2-methyl-propyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 95 percent / lithium-tri-tert-butoxyaluminohydride / tetrahydrofuran / 0.5 h / 0 °C
2: triethylamine, 4-dimethylaminopyridine / CH2Cl2 / 20 h
With
dmap; lithium tri(t-butoxy)aluminum hydride; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)81719-1
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium bicarbonate, KHSO5 / methanol; H2O / 2 h
2: 1.) 15percent n-butyllithium / 1.) THF, hexane, - 78 deg C, 20 min, 2.) THF, hexane, - 78 deg C
3: 60 percent / disodium hydrogen phosphate, 5percent sodium amalgam / tetrahydrofuran; methanol / 1 h / Ambient temperature
4: 95 percent / lithium-tri-tert-butoxyaluminohydride / tetrahydrofuran / 0.5 h / 0 °C
5: triethylamine, 4-dimethylaminopyridine / CH2Cl2 / 20 h
With
dmap; disodium hydrogenphosphate; sodium amalgam; potassium peroxomonosulfate; n-butyllithium; lithium tri(t-butoxy)aluminum hydride; sodium hydrogencarbonate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/S0040-4020(01)81719-1
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) 15percent n-butyllithium / 1.) THF, hexane, - 78 deg C, 20 min, 2.) THF, hexane, - 78 deg C
2: 60 percent / disodium hydrogen phosphate, 5percent sodium amalgam / tetrahydrofuran; methanol / 1 h / Ambient temperature
3: 95 percent / lithium-tri-tert-butoxyaluminohydride / tetrahydrofuran / 0.5 h / 0 °C
4: triethylamine, 4-dimethylaminopyridine / CH2Cl2 / 20 h
With
dmap; disodium hydrogenphosphate; sodium amalgam; n-butyllithium; lithium tri(t-butoxy)aluminum hydride; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)81719-1