C₂₂H₂₇ClN₂O

Base Information

• Chemical Name: C₂₂H₂₇ClN₂O
• CAS No.: 1437759-76-6
• Molecular Formula: C₂₂H₂₇ClN₂O
• Molecular Weight: 370.922
• Mol file: 1437759-76-6.mol

Synonyms:

Chemical Property of C₂₂H₂₇ClN₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₇ClN₂O

There total 1 articles about C₂₂H₂₇ClN₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-N-phenylpiperidin-4-amine (1155-56-2) + 2-chlorobutyryl chloride (7623-11-2) → C22H27ClN2O (1437759-76-6)

Guidance literature:

With sodium hydroxide; In dichloromethane; water; at 20 ℃;

DOI:10.1016/j.bmcl.2013.03.101

Reference yield:

C22H27ClN2O (1437759-76-6) → C22H26N2O (1437759-78-8)

Guidance literature:

With aluminum (III) chloride; at 130 - 160 ℃;

DOI:10.1016/j.bmcl.2013.03.101

Reference yield:

C22H27ClN2O (1437759-76-6) → C24H36N2O + C24H36N2O

Guidance literature:

Multi-step reaction with 3 steps

1: aluminum (III) chloride / 130 - 160 °C

2: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 20 °C / 760.05 Torr

3: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C

With aluminum (III) chloride; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; In methanol; 1,2-dichloro-ethane; 1: |Friedel-Crafts Alkylation;

DOI:10.1016/j.bmcl.2013.03.101

upstream raw materials:

1-benzyl-N-phenylpiperidin-4-amine

2-chlorobutyryl chloride

Downstream raw materials:

C₂₂H₂₆N₂O

Refernces