2,6-Dimethoxybiphenyl

Base Information

• Chemical Name: 2,6-Dimethoxybiphenyl
• CAS No.: 13732-86-0
• Molecular Formula: C14H14O2
• Molecular Weight: 214.264
• DSSTox Substance ID: DTXSID80358758
• Nikkaji Number: J469.847I
• Wikidata: Q82139589
• Mol file: 13732-86-0.mol

Synonyms:2,6-dimethoxybiphenyl;1,3-dimethoxy-2-phenylbenzene;13732-86-0;2,6-DIMETHOXY-1,1'-BIPHENYL;SCHEMBL355567;2-phenyl-1,3-dimethoxybenzene;DTXSID80358758;CKZBRKLFMRHHMA-UHFFFAOYSA-N;STL324948;AKOS022120020;CS-0242445;EN300-249333

Chemical Property of 2,6-Dimethoxybiphenyl

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 214.099379685
• Heavy Atom Count: 16
• Complexity: 187

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=CC=C1)OC)C2=CC=CC=C2

Technology Process of 2,6-Dimethoxybiphenyl

There total 3 articles about 2,6-Dimethoxybiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

carbon dioxide (124-38-9,18923-20-1) + chlorobenzene (108-90-7) + 1,3-Dimethoxybenzene (151-10-0) → 2,6-dimethoxybiphenyl (13732-86-0) + 2-6-dimethoxybenzoic acid (1466-76-8)

Guidance literature:

chlorobenzene; 1,3-Dimethoxybenzene; With sodium; In toluene; at 20 ℃;

carbon dioxide; In toluene; at 20 ℃;

DOI:10.1002/1521-3773(20020118)41:2<340::AID-ANIE340>3.0.CO;2-D

Reference yield: 34.0%

dimethyl sulfate (77-78-1) + 1,3-Dimethoxybenzene (151-10-0) → 2,6-dimethoxybiphenyl (13732-86-0) + 2,6-dimethoxytoluene (5673-07-4)

Guidance literature:

1,3-Dimethoxybenzene; With sodium; chlorobenzene;

dimethyl sulfate;

Reference yield:

2,6-dinitrobiphenyl (5110-81-6) + sodium methylate (124-41-4) → 2,6-dimethoxybiphenyl (13732-86-0) + 6,6'-dimethoxy-2,2'-azoxybiphenyl (84251-04-7)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; for 22h;

upstream raw materials:

2,6-dinitrobiphenyl

sodium methylate

carbon dioxide

chlorobenzene

Downstream raw materials:

(R)-1-fluoro-6-methoxy-[1,1‘-biphenyl-2(1H)]-one

dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane

2',2'',4'',6'-tetramethoxy-[1,1':3',1'':3'',1'''-quaterphenyl]-4',6''-diol

pyrene

Refernces

• 1、 -. "Method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group". Page column 9. . Retrieved 2010/01/31.