cyclo-L-Tyr-L-Tyr

Base Information

• Chemical Name: cyclo-L-Tyr-L-Tyr
• CAS No.: 1445324-30-0
• Molecular Formula: C₁₈H₁₈N₂O₄
• Molecular Weight: 326.352
• Mol file: 1445324-30-0.mol

Synonyms:

Chemical Property of cyclo-L-Tyr-L-Tyr

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclo-L-Tyr-L-Tyr

There total 8 articles about cyclo-L-Tyr-L-Tyr which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H30N2O7 → cyclo-L-Tyr-L-Tyr (1445324-30-0)

Guidance literature:

C₂₄H₃₀N₂O₇; With formic acid; at 26 ℃; Inert atmosphere;

In isopropyl alcohol; toluene; at 120 ℃; Inert atmosphere;

DOI:10.1021/jacs.8b10212

Reference yield:

tyrosine (556-02-5,18875-48-4,25619-78-7,30704-25-7) → cyclo-L-Tyr-L-Tyr (1445324-30-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / water; 1,4-dioxane / Inert atmosphere

2.1: triethylamine; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 12 h / 0 - 26 °C / Inert atmosphere

3.1: formic acid / 26 °C / Inert atmosphere

3.2: 120 °C / Inert atmosphere

With formic acid; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1021/jacs.8b10212

Reference yield:

C33H46N2O8 → cyclo-L-Tyr-L-Tyr (1445324-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid; trifluoroacetic acid; water / 2 h / 20 °C

2: butan-1-ol / 2 h / Reflux

With formic acid; water; trifluoroacetic acid; In butan-1-ol;

DOI:10.1074/jbc.M112.443853

upstream raw materials:

(D-Tyr)-(D-Tyr)

C₁₄H₂₁NO₃

tyrosine

N-(tert-butoxycarbonyl)-D-tyrosine

Refernces

• 1、 Fonvielle, Matthieu,Le Du, Marie-Helene,Lequin, Olivier,Lecoq, Alain,Jacquet, Mickael,Thai, Robert,Dubois, Steven,Grach, Guillaume,Gondry, Muriel,Belin, Pascal. "Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121: Insights from biochemical studies and crystal structures". . p. 17347 - 17359. Retrieved 2013/07/27.