Technology Process of N,N,N',N'-tetraisopropyl-2-bromoisophthalamide
There total 1 articles about N,N,N',N'-tetraisopropyl-2-bromoisophthalamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
n-butyl lithium;
In
tetrahydrofuran; hexane;
soln. of n-BuLi in hexane added dropwise to soln. of bromide in THF at -78°C under Ar; mixt. stirred for 1 h; soln. of B compd. in THF added dropwise at -78°C; mixt stirred at -78°C for 3 h; slowly warmed to room temp. within 15 h; aq. HCl added; stirred for 1 h; extn. with CH2Cl2; org. layer washed with brine; dried over Na2SO4; filtrate evapd.;
DOI:10.1246/bcsj.20090342
- Guidance literature:
-
N,N,N',N'-tetraisopropyl-2-bromoisophthalamide;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
With
Trimethyl borate;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 18h;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; hexane; water;
for 1h;
DOI:10.1246/bcsj.20090342
