4-(3',4'-dimethoxyphenyl)-2,3-dibromocrotonolactone

Base Information

• Chemical Name: 4-(3',4'-dimethoxyphenyl)-2,3-dibromocrotonolactone
• CAS No.: 92576-92-6
• Molecular Formula: C₁₂H₁₀Br₂O₄
• Molecular Weight: 378.017
• Mol file: 92576-92-6.mol

Synonyms:

Chemical Property of 4-(3',4'-dimethoxyphenyl)-2,3-dibromocrotonolactone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3',4'-dimethoxyphenyl)-2,3-dibromocrotonolactone

There total 2 articles about 4-(3',4'-dimethoxyphenyl)-2,3-dibromocrotonolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

mucobromic acid (766-38-1) + 1,2-dimethoxybenzene (91-16-7) → 4-(3',4'-dimethoxyphenyl)-2,3-dibromocrotonolactone (92576-92-6)

Guidance literature:

With aluminium trichloride; for 3h;

DOI:10.1002/jhet.5570350634

Reference yield:

→ 4-(3',4'-dimethoxyphenyl)-2,3-dibromocrotonolactone (92576-92-6)

Guidance literature:

2,3-Dibrom-3-formyl-acrylsaeure, H3PO4, P2O5, 1,2-Dimethoxybenzol;

Reference yield: 40.0%

4-(3',4'-dimethoxyphenyl)-2,3-dibromocrotonolactone (92576-92-6) → (E)-3-bromo-3-(3,4-dimethoxybenzoyl)acrylic acid (220967-25-9)

Guidance literature:

With water; magnesium oxide; In 1,4-dioxane; for 1.25h; Heating;

DOI:10.1002/jhet.5570350634

upstream raw materials:

mucobromic acid

1,2-dimethoxybenzene

Downstream raw materials:

(E)-3-bromo-3-(3,4-dimethoxybenzoyl)acrylic acid

5-bromo-6-(3',4'-dimethoxyphenyl)-3(2H)-pyridazinone

Refernces

• 1、 Estevez, Isabel,Ravina, Enrique,Sotelo, Eddy. "Pyridazines. XV. Synthesis of 6-aryl-5-amino-3(2H)-pyridazinones as potential platelet aggregation inhibitors". . p. 1421 - 1428. Retrieved 2007/10/03.