dibenzyl <2-13C>malonate

Base Information

• Chemical Name: dibenzyl <2-13C>malonate
• CAS No.: 67024-20-8
• Molecular Formula: C₁₇H₁₆O₄
• Molecular Weight: 285.301
• Mol file: 67024-20-8.mol

Synonyms:

Chemical Property of dibenzyl <2-13C>malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibenzyl <2-13C>malonate

There total 1 articles about dibenzyl <2-13C>malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-13C] malonic acid (55514-11-9) + benzyl alcohol (100-51-6,185532-71-2) → dibenzyl <2-13C>malonate (67024-20-8)

Guidance literature:

With sulfuric acid; In benzene; for 1h; Heating;

DOI:10.1039/P19810002786

Reference yield:

dibenzyl <2-13C>malonate (67024-20-8) → dibenzyl hydroxyimino<2-13C>malonate (80504-89-8)

Guidance literature:

With sodium nitrate; In water; acetic acid; for 20h;

DOI:10.1039/P19810002786

Reference yield:

dibenzyl <2-13C>malonate (67024-20-8) → C18(13)CH21NO6

Guidance literature:

Multi-step reaction with 4 steps

1: 8.26 g / NaNO₃ / H₂O; acetic acid / 20 h

2: Zn, HOAc, NaOAc / H₂O / 0.75 h / 105 - 115 °C

3: 95.4 percent / SOCl₂ / CH₂Cl₂

4: 79.2 percent / (Ph₃P)3RhCl / toluene

With sodium nitrate; Wilkinson's catalyst; thionyl chloride; sodium acetate; acetic acid; zinc; In dichloromethane; water; acetic acid; toluene;

DOI:10.1039/P19810002786

upstream raw materials:

[2-13C] malonic acid

benzyl alcohol

Downstream raw materials:

dibenzyl hydroxyimino<2-13C>malonate

benzyl 3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-5-methyl<2-13C>pyrrole-2-carboxylate

C₁₉⁽¹³⁾CH₂₁NO₇

Refernces