(2,4-DIHYDROXYPHENYL)(4-METHOXYPHENYL)METHANONE

Base Information

• Chemical Name: (2,4-DIHYDROXYPHENYL)(4-METHOXYPHENYL)METHANONE
• CAS No.: 5298-27-1
• Molecular Formula: C14H12 O4
• Molecular Weight: 244.2427
• Hs Code.: 2914509090
• Mol file: 5298-27-1.mol

Synonyms:Benzophenone, 2,4-dihydroxy-4'-methoxy- (6CI,7CI,8CI);2,4-Dihydroxy-4'-methoxybenzophenone; NSC 508747

Chemical Property of (2,4-DIHYDROXYPHENYL)(4-METHOXYPHENYL)METHANONE

Chemical Property:

• Vapor Pressure: 7.91E-09mmHg at 25°C
• Melting Point: 159 °C
• Boiling Point: 453.1°Cat760mmHg
• PKA: 7.42±0.35(Predicted)
• Flash Point: 175.7°C
• PSA: 66.76000
• Density: 1.296g/cm³
• LogP: 2.33740

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2,4-DIHYDROXYPHENYL)(4-METHOXYPHENYL)METHANONE

There total 4 articles about (2,4-DIHYDROXYPHENYL)(4-METHOXYPHENYL)METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

bis(4-methoxy-phenyl)-iodonium cation (46835-94-3) + 2,4-Dihydroxybenzaldehyde (95-01-2) → (2,4-dihydroxyphenyl)(4-methoxyphenyl)methanone (5298-27-1)

Guidance literature:

With sodium carbonate; lithium chloride; palladium dichloride; In N,N-dimethyl-formamide; at 60 ℃; for 4h;

DOI:10.1080/00397910008087349

Reference yield:

4-methoxy-benzoyl chloride (100-07-2) + recorcinol (108-46-3) → (2,4-dihydroxyphenyl)(4-methoxyphenyl)methanone (5298-27-1)

Guidance literature:

With aluminium trichloride; nitrobenzene;

DOI:10.1039/jr9500002381

Reference yield:

4-methoxybenzoic acid (100-09-4) + recorcinol (108-46-3) → (2,4-dihydroxyphenyl)(4-methoxyphenyl)methanone (5298-27-1)

Guidance literature:

With hydrogen fluoride; at 100 ℃; unter Druck;

DOI:10.1021/jo01373a005

upstream raw materials:

4-methoxy-benzoyl chloride

recorcinol

4-methoxybenzoic acid

bis(4-methoxy-phenyl)-iodonium cation

Downstream raw materials:

6-methoxy-3-(4-methoxy-phenyl)-benzofuran-2-carboxylic acid

[5-methoxy-2-(4-methoxy-benzoyl)-phenoxy]-acetic acid

3-(4-methoxyphenyl)-6-methoxy-1-benzofuran

(2-Hydroxy-4-methoxy-phenyl)-(4-methoxy-phenyl)-methanone oxime

Refernces

• 1、 Xia, Min,Chen, ZhenChu. "Hypervalent iodine in synthesis XXXIV: Palladium-catalyzed coupling reaction of o-hydroxyarylaldehydes with hypervalent iodonium salts via cleavage of the aldehyde C-H bond". . p. 531 - 536. Retrieved 2007/10/03.