13β-Aethyl-3-methoxy-gonapentaen-(1.3.5(10).8.14)-ol-(17β)-acetat

Base Information

• Chemical Name: 13β-Aethyl-3-methoxy-gonapentaen-(1.3.5(10).8.14)-ol-(17β)-acetat
• CAS No.: 2911-81-1
• Molecular Formula: C₂₂H₂₆O₃
• Molecular Weight: 338.447
• Mol file: 2911-81-1.mol

Synonyms:

Chemical Property of 13β-Aethyl-3-methoxy-gonapentaen-(1.3.5(10).8.14)-ol-(17β)-acetat

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

13-Ethyl-3-methoxygona-1,3,5(10)-8,14-pentaen-17β-ol-acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 13-Ethyl-3-methoxygona-1,3,5(10)-8,14-pentaen-17β-ol-acetate is a useful synthetic intermediate in the synthesis of some 8α-analogs of steroid estrogens with potential osteoprotective properties.

Technology Process of 13β-Aethyl-3-methoxy-gonapentaen-(1.3.5(10).8.14)-ol-(17β)-acetat

There total 1 articles about 13β-Aethyl-3-methoxy-gonapentaen-(1.3.5(10).8.14)-ol-(17β)-acetat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 13β-Aethyl-3-methoxy-gonapentaen-(1.3.5(10).8.14)-ol-(17β)-acetat (2911-81-1,5941-86-6,85760-97-0)

Guidance literature:

Entspr. Alkohol, Ac2O;

Reference yield:

13β-Aethyl-3-methoxy-gonapentaen-(1.3.5(10).8.14)-ol-(17β)-acetat (2911-81-1,5941-86-6,85760-97-0) → 18-methyl-3-methoxy-1,3,5(10),8-estratetraen-17β-ol (7443-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd-CaCO₃ / benzene; tetrahydrofuran

2: KOH / methanol

With potassium hydroxide; hydrogen; Lindlar's catalyst; In tetrahydrofuran; methanol; benzene;

DOI:10.1002/jlac.19677020118

Reference yield:

13β-Aethyl-3-methoxy-gonapentaen-(1.3.5(10).8.14)-ol-(17β)-acetat (2911-81-1,5941-86-6,85760-97-0) → levonorgestrel (797-63-7)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / Pd-CaCO₃ / benzene; tetrahydrofuran

2: KOH / methanol

3: (i) LiNH₂, liq. NH₃, PhNH₂, THF, (ii) AcOH, EtOH

4: Al(OiPr)3 / butan-2-one; benzene / Heating

5: (i) Li, H₂NCH₂CH₂NH₂, THF, (ii) aq. HCl, MeOH

With potassium hydroxide; hydrogen; aluminum isopropoxide; Lindlar's catalyst; In tetrahydrofuran; methanol; butanone; benzene;

DOI:10.1002/jlac.19677020118

Downstream raw materials:

D-17β-acetoxy-13β-ethyl-17α-ethynyl-gon-4-en-3-one

18-methyl-3-methoxy-1,3,5(10),8-estratetraen-17β-ol

D-13β-ethyl-17β-hydroxy-3-methoxy-gona-2,5(10)-diene

13β-ethyl-3-methoxy-17α-ethynyl-gona-2,5(10)-dien-17β-ol