Methyl L-2-hydroxy-3-methylbutanoate (S)-MTPA ester

Base Information

• Chemical Name: Methyl L-2-hydroxy-3-methylbutanoate (S)-MTPA ester
• CAS No.: 90211-80-6
• Molecular Formula: C₁₆H₁₉F₃O₅
• Molecular Weight: 348.319
• Mol file: 90211-80-6.mol

Synonyms:

Chemical Property of Methyl L-2-hydroxy-3-methylbutanoate (S)-MTPA ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl L-2-hydroxy-3-methylbutanoate (S)-MTPA ester

There total 4 articles about Methyl L-2-hydroxy-3-methylbutanoate (S)-MTPA ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → Methyl L-2-hydroxy-3-methylbutanoate (S)-MTPA ester (90211-80-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 58 percent / sodium nitrite / aq. H₂SO₄ / 2 h / 0 °C

2: 96 percent / diethyl ether / 0 °C

3: 130 mg / 4-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

With dmap; sodium nitrite; In diethyl ether; dichloromethane; sulfuric acid;

Reference yield:

(S)-2-Hydroxy-3-methylbutanoic acid (17407-55-5) → Methyl L-2-hydroxy-3-methylbutanoate (S)-MTPA ester (90211-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / diethyl ether / 0 °C

2: 130 mg / 4-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

With dmap; In diethyl ether; dichloromethane;

Reference yield:

(S)-Mosher acid (17257-71-5,20445-31-2,56135-03-6,81655-41-6) → Methyl L-2-hydroxy-3-methylbutanoate (S)-MTPA ester (90211-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride

2: 130 mg / 4-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

With dmap; oxalyl dichloride; In dichloromethane;

upstream raw materials:

(R)-methoxytrifluoromethylphenylacetyl chloride

methyl (S)-2-hydroxy-3-methylbutanoate

L-valine

(S)-2-Hydroxy-3-methylbutanoic acid

Refernces