Technology Process of N-{4-[2-(2-hydroxy-ethyl)-phenyl]-pyridin-3-yl}-N-methyl-3,5-bis-trifluoromethyl-benzamide
There total 7 articles about N-{4-[2-(2-hydroxy-ethyl)-phenyl]-pyridin-3-yl}-N-methyl-3,5-bis-trifluoromethyl-benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C
1.2: 1 h / -78 °C
2.1: water; sodium carbonate / triphenylphosphine; palladium diacetate / 1,2-dimethoxyethane / 18 h / 90 °C / Inert atmosphere
With
water; sodium carbonate; lithium hexamethyldisilazane;
palladium diacetate; triphenylphosphine;
In
tetrahydrofuran; 1,2-dimethoxyethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride; water / 18 h / 100 °C
1.2: pH 9 / Cooling
2.1: trifluoroacetic acid / 2 h / Reflux
2.2: 0 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C
3.2: 1 h / -78 °C
4.1: water; sodium carbonate / triphenylphosphine; palladium diacetate / 1,2-dimethoxyethane / 18 h / 90 °C / Inert atmosphere
With
hydrogenchloride; water; sodium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane;
palladium diacetate; triphenylphosphine;
In
tetrahydrofuran; 1,2-dimethoxyethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / 2 h / Reflux
1.2: 0 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C
2.2: 1 h / -78 °C
3.1: water; sodium carbonate / triphenylphosphine; palladium diacetate / 1,2-dimethoxyethane / 18 h / 90 °C / Inert atmosphere
With
water; sodium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane;
palladium diacetate; triphenylphosphine;
In
tetrahydrofuran; 1,2-dimethoxyethane;